| Psoriasis vulgaris
Duobrii vs Ultravate
Side-by-side clinical, coverage, and cost comparison for psoriasis vulgaris.Deep comparison between: Duobrii vs Ultravate with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsUltravate has a higher rate of injection site reactions vs Duobrii based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Ultravate but not Duobrii, including UnitedHealthcare
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Category
Duobrii
Ultravate
At A Glance
Topical
Once daily
Corticosteroid/retinoid combination
Topical
Twice daily
Topical corticosteroid
Indications
- Psoriasis vulgaris
- Psoriasis vulgaris
Dosing
Psoriasis vulgaris Apply a thin layer once daily to affected areas, rubbing in gently; total dosage should not exceed approximately 50 g per week; avoid application on the face, groin, or axillae; do not use with occlusive dressings unless directed by a physician; discontinue when control is achieved.
Psoriasis vulgaris Apply a thin layer to affected skin twice daily for up to two weeks; total dosage should not exceed 50 grams (50 ml) per week.
Contraindications
- Pregnancy
—
Adverse Reactions
Most common (>=1%) contact dermatitis, application site pain, folliculitis, skin atrophy, excoriation, rash, skin abrasion, skin exfoliation
Most common (>=1%) Telangiectasia, application site atrophy, headache
Less common (<1%, >0.1%) Application site discoloration, herpes zoster, influenza, nasopharyngitis, otitis media acute, throat infection, wound, increased blood pressure
Pharmacology
Combination of halobetasol propionate, a synthetic corticosteroid that modulates cellular signaling, immune function, and inflammation, and tazarotene, a retinoid prodrug converted by esterase hydrolysis to tazarotenic acid, which binds RAR-beta and RAR-gamma receptors to modify gene expression; precise mechanisms in plaque psoriasis are unknown.
Halobetasol propionate is a super-high potency topical corticosteroid that plays a role in cellular signaling, immune function, inflammation, and protein regulation; the precise mechanism of action in plaque psoriasis is unknown.
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Most Common Insurance
Anthem BCBS
Duobrii
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (9/12) · Qty limit (9/12)
Ultravate
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (5/12) · Qty limit (9/12)
UnitedHealthcare
Duobrii
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (1/8) · Qty limit (1/8)
Ultravate
- Covered on 4 commercial plans
- PA (1/8) · Step Therapy (1/8) · Qty limit (0/8)
Humana
Duobrii
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (2/3)
Ultravate
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Duobrii.
No savings programs available for Ultravate.
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DuobriiView full Duobrii profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.