| Psoriasis vulgaris
Enstilar vs Lexette
Side-by-side clinical, coverage, and cost comparison for psoriasis vulgaris.Deep comparison between: Enstilar vs Lexette with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsLexette has a higher rate of injection site reactions vs Enstilar based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Lexette but not Enstilar, including UnitedHealthcare
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Category
Enstilar
Lexette
At A Glance
Topical
Once daily
Vitamin D3 analog + corticosteroid
Topical
Twice daily
Corticosteroid
Indications
- Psoriasis vulgaris
- Psoriasis vulgaris
Dosing
Psoriasis vulgaris Apply to affected areas once daily for up to 4 weeks; maximum dose not to exceed 60 g every 4 days; rub in gently; do not use with occlusive dressings, on the face, groin, or axillae, or if skin atrophy is present at the treatment site.
Psoriasis vulgaris Apply a thin uniform film to affected skin twice daily for up to 2 weeks; shake can and invert before use; do not exceed 50 g per week; avoid face, groin, and axillae; not for use with occlusive dressings unless directed by physician.
Contraindications
—
—
Adverse Reactions
Postmarketing Application site burning, atrophy, striae, telangiectasia, dryness, perioral dermatitis, secondary infection, miliaria, cataracts, glaucoma, increased intraocular pressure.
Most common (>=1%) Application site burning/stinging, application site pain, headache
Postmarketing Folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, irritation, striae, miliaria
Pharmacology
Enstilar Foam combines calcipotriene hydrate, a synthetic vitamin D3 analog, and betamethasone dipropionate, a synthetic corticosteroid; exact mechanisms of action in the treatment of plaque psoriasis are unknown.
Topical super-high potency corticosteroid; halobetasol propionate plays a role in cellular signaling, immune function, inflammation, and protein regulation, though its precise mechanism of action in plaque psoriasis is unknown.
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Most Common Insurance
Anthem BCBS
Enstilar
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (10/12) · Qty limit (9/12)
Lexette
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (5/12) · Qty limit (9/12)
UnitedHealthcare
Enstilar
- Covered on 4 commercial plans
- PA (1/8) · Step Therapy (0/8) · Qty limit (3/8)
Lexette
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Enstilar
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (2/3)
Lexette
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
$30/fillfill
Leo Copay Savings Card: EnstilarCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
No savings programs available for Lexette.
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EnstilarView full Enstilar profile
LexetteView full Lexette profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.