| Renal transplant rejection
Thymoglobulin vs Nulojix
Side-by-side clinical, coverage, and cost comparison for renal transplant rejection.Deep comparison between: Thymoglobulin vs Nulojix with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsNulojix has a higher rate of injection site reactions vs Thymoglobulin based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Nulojix but not Thymoglobulin, including UnitedHealthcare
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Category
Thymoglobulin
Nulojix
At A Glance
IV infusion
Daily
Polyclonal anti-thymocyte globulin
IV infusion
Every 4 weeks
Selective T cell costimulation blocker
Indications
- Renal transplant rejection
- Renal transplant rejection
Dosing
Renal transplant rejection (prophylaxis) 1.5 mg/kg IV daily for 4 to 7 days; first dose infused over at least 6 hours, subsequent doses over at least 4 hours; premedicate with corticosteroids, acetaminophen, and/or antihistamine 1 hour prior to each infusion.
Renal transplant rejection (treatment) 1.5 mg/kg IV daily for 7 to 14 days; first dose infused over at least 6 hours, subsequent doses over at least 4 hours; premedicate with corticosteroids, acetaminophen, and/or antihistamine 1 hour prior to each infusion.
Renal transplant rejection Initial phase: 10 mg/kg IV on Day 1, Day 5, and end of Weeks 2, 4, 8, and 12; maintenance phase starting Week 16: 5 mg/kg IV every 4 weeks (+/- 3 days), administered over 30 minutes.
Contraindications
- History of allergy or anaphylactic reaction to rabbit proteins or to any product excipients
- Active acute or chronic infections that contraindicate additional immunosuppression
- EBV seronegative or unknown EBV serostatus, due to risk of post-transplant lymphoproliferative disorder (PTLD) predominantly involving the CNS
Adverse Reactions
Most common (>5% higher than comparator) Urinary tract infection, abdominal pain, hypertension, nausea, dyspnea, fever, headache, anxiety, chills, hyperkalemia, leukopenia, thrombocytopenia
Serious Malignancies (including PTLD and lymphoma), anaphylactic shock, serum sickness, severe infections including sepsis
Postmarketing Hepatic dysfunction, hepatic failure, hyperbilirubinemia, febrile neutropenia, coagulopathy, disseminated intravascular coagulopathy, hemolytic anemia, thrombotic microangiopathy, anaphylaxis, cytokine release syndrome
Most common (>=20%) Anemia, diarrhea, urinary tract infection, peripheral edema, constipation, hypertension, pyrexia, graft dysfunction, cough, nausea, vomiting, headache, hypokalemia, hyperkalemia, leukopenia
Serious PTLD predominantly involving the CNS, serious infections including JC virus-associated PML and polyoma virus nephropathy
Postmarketing Anaphylaxis, venous thrombosis of the renal allograft
Pharmacology
Polyclonal anti-thymocyte immunoglobulin G derived from rabbit immunization with human thymocytes; suppresses immune responses via T-cell clearance and modulation of T-cell activation, homing, and cytotoxic activities through antibodies targeting CD2, CD3, CD4, CD8, CD11a, CD18, CD25, CD44, CD45, HLA-DR, HLA Class I heavy chains, and beta2-microglobulin.
Selective T cell costimulation blocker; belatacept is a soluble CTLA4-Ig fusion protein that binds CD80 and CD86 on antigen-presenting cells, blocking CD28-mediated T lymphocyte costimulation and inhibiting T cell proliferation and cytokine production that mediate immunologic rejection.
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Most Common Insurance
Anthem BCBS
Thymoglobulin
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (0/12) · Qty limit (0/12)
Nulojix
- Covered on 5 commercial plans
- PA (12/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Thymoglobulin
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Nulojix
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Thymoglobulin
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (0/3)
Nulojix
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableHealthWell: Immunosuppressive Treatment for Solid Organ Transplant Recipients - Medicare Access
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
$50/fillfill
BMS Kidney Transplant Co-Pay Assistance Program: NulojixCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
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ThymoglobulinView full Thymoglobulin profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.