| Rosacea
Epsolay vs Mirvaso
Side-by-side clinical, coverage, and cost comparison for rosacea.Deep comparison between: Epsolay vs Mirvaso with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsMirvaso has a higher rate of injection site reactions vs Epsolay based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Mirvaso but not Epsolay, including UnitedHealthcare
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Category
Epsolay
Mirvaso
At A Glance
Topical
Once daily
Oxidizing agent
Topical
Once daily
Alpha-2 adrenergic agonist
Indications
- Rosacea
- Rosacea
Dosing
Rosacea Apply a pea-sized amount once daily in a thin layer to each area of the face (forehead, chin, nose, each cheek) on clean and dry skin; avoid eyes, lips, and mouth.
Rosacea Apply a pea-sized amount once daily to each of the five areas of the face (central forehead, chin, nose, each cheek) as a thin layer across the entire face, avoiding the eyes and lips; wash hands after applying.
Contraindications
- History of hypersensitivity reactions to benzoyl peroxide or any components of the formulation
- Hypersensitivity reaction to any component of MIRVASO topical gel (reactions have included angioedema, urticaria, and contact dermatitis)
Adverse Reactions
Most common (>=1%) Application site pain, erythema, pruritus, edema
Most common (>=1%) Erythema, flushing, skin burning sensation, contact dermatitis, dermatitis, skin warmth, paraesthesia, acne, skin pain, blurred vision, nasal congestion
Postmarketing Bradycardia, hypotension, angioedema, hypersensitivity, lip swelling, swollen tongue, throat tightness, urticaria, dizziness, pallor
Pharmacology
Benzoyl peroxide is an oxidizing agent with bactericidal and keratolytic effects; the precise mechanism of action in the treatment of rosacea is unknown.
Brimonidine is a relatively selective alpha-2 adrenergic agonist; topical application of MIRVASO topical gel may reduce facial erythema through direct vasoconstriction.
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Most Common Insurance
Anthem BCBS
Epsolay
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (0/12) · Qty limit (9/12)
Mirvaso
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (5/12) · Qty limit (0/12)
UnitedHealthcare
Epsolay
- Covered on 4 commercial plans
- PA (1/8) · Step Therapy (1/8) · Qty limit (0/8)
Mirvaso
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Epsolay
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (2/3) · Qty limit (2/3)
Mirvaso
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Epsolay.
No savings programs available for Mirvaso.
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EpsolayView full Epsolay profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.