| Rosacea
Epsolay vs Zilxi
Side-by-side clinical, coverage, and cost comparison for rosacea.Deep comparison between: Epsolay vs Zilxi with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsZilxi has a higher rate of injection site reactions vs Epsolay based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Zilxi but not Epsolay, including UnitedHealthcare
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Category
Epsolay
Zilxi
At A Glance
Topical
Once daily
Oxidizing agent
Topical
Daily
Tetracycline derivative
Indications
- Rosacea
- Rosacea
Dosing
Rosacea Apply a pea-sized amount once daily in a thin layer to each area of the face (forehead, chin, nose, each cheek) on clean and dry skin; avoid eyes, lips, and mouth.
Rosacea Apply a cherry-sized amount of foam to the entire face once daily at least 1 hour before bedtime; do not bathe, shower, or swim for at least 1 hour after application.
Contraindications
- History of hypersensitivity reactions to benzoyl peroxide or any components of the formulation
- Hypersensitivity to any tetracycline or any other ingredient in ZILXI
Adverse Reactions
Most common (>=1%) Application site pain, erythema, pruritus, edema
Most common (>=1%) Diarrhea
Pharmacology
Benzoyl peroxide is an oxidizing agent with bactericidal and keratolytic effects; the precise mechanism of action in the treatment of rosacea is unknown.
Minocycline is a semi-synthetic derivative of tetracycline; its mechanism of action for the treatment of inflammatory lesions of rosacea is unknown.
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Most Common Insurance
Anthem BCBS
Epsolay
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (0/12) · Qty limit (9/12)
Zilxi
- Covered on 5 commercial plans
- PA (4/12) · Step Therapy (4/12) · Qty limit (9/12)
UnitedHealthcare
Epsolay
- Covered on 4 commercial plans
- PA (1/8) · Step Therapy (1/8) · Qty limit (0/8)
Zilxi
- Covered on 4 commercial plans
- PA (3/8) · Step Therapy (3/8) · Qty limit (3/8)
Humana
Epsolay
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (2/3) · Qty limit (2/3)
Zilxi
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (2/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Epsolay.
No savings programs available for Zilxi.
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EpsolayView full Epsolay profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.