| Rosacea
Oracea vs Zilxi
Side-by-side clinical, coverage, and cost comparison for rosacea.Deep comparison between: Oracea vs Zilxi with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsZilxi has a higher rate of injection site reactions vs Oracea based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Zilxi but not Oracea, including UnitedHealthcare
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Category
Oracea
Zilxi
At A Glance
Oral
Daily
Tetracycline-class antibiotic
Topical
Daily
Tetracycline derivative
Indications
- Rosacea
- Rosacea
Dosing
Rosacea 40 mg once daily in the morning on an empty stomach, preferably at least one hour prior to or two hours after meals, administered orally.
Rosacea Apply a cherry-sized amount of foam to the entire face once daily at least 1 hour before bedtime; do not bathe, shower, or swim for at least 1 hour after application.
Contraindications
- Hypersensitivity to doxycycline or any of the other tetracyclines
- Hypersensitivity to any tetracycline or any other ingredient in ZILXI
Adverse Reactions
Most common (>=1%) nasopharyngitis, diarrhea, hypertension, sinusitis, fungal infection, influenza, aspartate aminotransferase increase, blood pressure increase, anxiety, pain, abdominal pain upper, blood lactate dehydrogenase increase, nasal congestion, abdominal distention, abdominal pain, stomach discomfort, dry mouth, blood glucose increase, back pain, sinus headache, pharyngolaryngeal pain
Serious hepatotoxicity, esophagitis, esophageal ulcerations, renal toxicity (rise in BUN), exfoliative dermatitis, photosensitivity, urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, serum sickness, pericarditis, exacerbation of systemic lupus erythematosus, hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia
Postmarketing pseudotumor cerebri (benign intracranial hypertension), headache, fixed drug eruption, depression, anxiety, suicidal ideation, insomnia, abnormal dreams, hallucination
Most common (>=1%) Diarrhea
Pharmacology
Doxycycline is a member of the tetracycline-class of drugs; the plasma concentrations achieved with ORACEA are sub-antimicrobial, and the mechanism of action in the treatment of inflammatory lesions of rosacea is unknown.
Minocycline is a semi-synthetic derivative of tetracycline; its mechanism of action for the treatment of inflammatory lesions of rosacea is unknown.
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Most Common Insurance
Anthem BCBS
Oracea
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (9/12) · Qty limit (10/12)
Zilxi
- Covered on 5 commercial plans
- PA (4/12) · Step Therapy (4/12) · Qty limit (9/12)
UnitedHealthcare
Oracea
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Zilxi
- Covered on 4 commercial plans
- PA (3/8) · Step Therapy (3/8) · Qty limit (3/8)
Humana
Oracea
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (2/3) · Qty limit (2/3)
Zilxi
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (2/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Oracea.
No savings programs available for Zilxi.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.