| Rosacea
Zilxi vs Mirvaso
Side-by-side clinical, coverage, and cost comparison for rosacea.Deep comparison between: Zilxi vs Mirvaso with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsMirvaso has a higher rate of injection site reactions vs Zilxi based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Mirvaso but not Zilxi, including UnitedHealthcare
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Category
Zilxi
Mirvaso
At A Glance
Topical
Daily
Tetracycline derivative
Topical
Once daily
Alpha-2 adrenergic agonist
Indications
- Rosacea
- Rosacea
Dosing
Rosacea Apply a cherry-sized amount of foam to the entire face once daily at least 1 hour before bedtime; do not bathe, shower, or swim for at least 1 hour after application.
Rosacea Apply a pea-sized amount once daily to each of the five areas of the face (central forehead, chin, nose, each cheek) as a thin layer across the entire face, avoiding the eyes and lips; wash hands after applying.
Contraindications
- Hypersensitivity to any tetracycline or any other ingredient in ZILXI
- Hypersensitivity reaction to any component of MIRVASO topical gel (reactions have included angioedema, urticaria, and contact dermatitis)
Adverse Reactions
Most common (>=1%) Diarrhea
Most common (>=1%) Erythema, flushing, skin burning sensation, contact dermatitis, dermatitis, skin warmth, paraesthesia, acne, skin pain, blurred vision, nasal congestion
Postmarketing Bradycardia, hypotension, angioedema, hypersensitivity, lip swelling, swollen tongue, throat tightness, urticaria, dizziness, pallor
Pharmacology
Minocycline is a semi-synthetic derivative of tetracycline; its mechanism of action for the treatment of inflammatory lesions of rosacea is unknown.
Brimonidine is a relatively selective alpha-2 adrenergic agonist; topical application of MIRVASO topical gel may reduce facial erythema through direct vasoconstriction.
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Most Common Insurance
Anthem BCBS
Zilxi
- Covered on 5 commercial plans
- PA (4/12) · Step Therapy (4/12) · Qty limit (9/12)
Mirvaso
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (5/12) · Qty limit (0/12)
UnitedHealthcare
Zilxi
- Covered on 4 commercial plans
- PA (3/8) · Step Therapy (3/8) · Qty limit (3/8)
Mirvaso
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Zilxi
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (2/3) · Qty limit (2/3)
Mirvaso
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Zilxi.
No savings programs available for Mirvaso.
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MirvasoView full Mirvaso profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.