| Schizophrenia
Abilify Asimtufii vs Cobenfy
Side-by-side clinical, coverage, and cost comparison for schizophrenia.Deep comparison between: Abilify Asimtufii vs Cobenfy with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsCobenfy has a higher rate of injection site reactions vs Abilify Asimtufii based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Cobenfy but not Abilify Asimtufii, including UnitedHealthcare
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Category
Abilify Asimtufii
Cobenfy
At A Glance
IM injection
Every 2 months
Atypical antipsychotic
Oral
Twice daily
Muscarinic agonist/antagonist combination
Indications
- Schizophrenia
- Bipolar I disorder
- Schizophrenia
Dosing
Schizophrenia, Bipolar I disorder 960 mg IM gluteal injection once every 2 months (56 days); dose may be reduced to 720 mg if adverse reactions occur; CYP2D6 poor metabolizers: 720 mg once every 2 months.
Schizophrenia Starting dose 50 mg/20 mg orally twice daily for at least 2 days, then 100 mg/20 mg twice daily for at least 5 days; may increase to 125 mg/30 mg twice daily based on tolerability and response (maximum dose); take at least 1 hour before or 2 hours after a meal; do not open capsules. Geriatric patients: start at 50 mg/20 mg twice daily, maximum 100 mg/20 mg twice daily.
Contraindications
- Known hypersensitivity to aripiprazole or any excipient
- Urinary retention
- Moderate (Child-Pugh Class B) or severe (Child-Pugh Class C) hepatic impairment
- Gastric retention
- History of hypersensitivity to COBENFY or trospium chloride
- Untreated narrow-angle glaucoma
Adverse Reactions
Most common (>=5%) Increased weight, akathisia, injection site pain, sedation
Serious Neuroleptic malignant syndrome, tardive dyskinesia, metabolic changes, orthostatic hypotension, leukopenia/neutropenia/agranulocytosis, seizures, dysphagia
Postmarketing Anaphylactic reaction, angioedema, DRESS, blood glucose fluctuation, pathological gambling, fecal incontinence, hiccups
Most common (>=5%) Nausea, dyspepsia, constipation, vomiting, hypertension, abdominal pain, diarrhea, tachycardia, dizziness, gastroesophageal reflux disease
Serious Urinary retention, liver enzyme elevations, increases in heart rate, angioedema
Postmarketing Chest pain, hypertensive crisis, palpitations, supraventricular tachycardia, syncope, gastritis, rash, rhabdomyolysis, confusion, delirium, hallucinations, somnolence, vision abnormal, angioedema, anaphylactic reaction, Stevens-Johnson syndrome (reported with trospium chloride component)
Pharmacology
Aripiprazole is an atypical antipsychotic whose efficacy may be mediated through partial agonist activity at dopamine D2 and serotonin 5-HT1A receptors and antagonist activity at serotonin 5-HT2A receptors; the active metabolite dehydro-aripiprazole also has affinity for D2 receptors.
Xanomeline is a muscarinic agonist with preferential activity at M1 and M4 receptors in the central nervous system, where its efficacy in schizophrenia is thought to arise; trospium chloride is a peripheral muscarinic antagonist included to reduce cholinergic adverse effects.
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Most Common Insurance
Anthem BCBS
Abilify Asimtufii
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (9/12) · Qty limit (11/12)
Cobenfy
- Covered on 5 commercial plans
- PA (12/12) · Step Therapy (8/12) · Qty limit (11/12)
UnitedHealthcare
Abilify Asimtufii
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Cobenfy
- Covered on 4 commercial plans
- PA (8/8) · Step Therapy (8/8) · Qty limit (2/8)
Humana
Abilify Asimtufii
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (3/3)
Cobenfy
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
$5/fillfill
Abilify Asimtufii Savings CardCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
$0/fillfill
Cobenfy Copay Assistance ProgramCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Abilify AsimtufiiView full Abilify Asimtufii profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.