| Seizures, Focal
Aptiom vs Briviact
Side-by-side clinical, coverage, and cost comparison for seizures, focal.Deep comparison between: Aptiom vs Briviact with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsBriviact has a higher rate of injection site reactions vs Aptiom based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Briviact but not Aptiom, including UnitedHealthcare
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Category
Aptiom
Briviact
At A Glance
Oral
Once daily
Sodium channel inhibitor
Oral; IV infusion
Twice daily
SV2A ligand
Indications
- Seizures, Focal
- Seizures, Focal
Dosing
Seizures, Focal (Adults) Initial 400 mg orally once daily; may initiate at 800 mg once daily if need for seizure reduction outweighs increased adverse reaction risk; increase weekly by 400-600 mg to recommended maintenance of 800-1600 mg once daily.
Seizures, Focal (Pediatric, 4-17 years) Weight-based once daily oral dosing; initial dose and titration increments per weight table; maintenance 400-1200 mg/day depending on body weight range (11-21 kg: 400-600 mg; 22-31 kg: 500-800 mg; 32-38 kg: 600-900 mg; >38 kg: 800-1200 mg).
Renal Impairment (Moderate or Severe) Reduce dosage by 50% in patients with creatinine clearance below 50 mL/min.
Seizures, Focal Adults (>=16 years): 50 mg twice daily (range 25-100 mg twice daily); pediatric patients >=50 kg: 25-50 mg twice daily (range 25-100 mg twice daily); pediatric patients <50 kg: weight-based dosing twice daily; IV injection at the same dose when oral administration is temporarily not feasible; dose adjustment required for all stages of hepatic impairment.
Contraindications
- Hypersensitivity to eslicarbazepine acetate or oxcarbazepine
- Hypersensitivity to brivaracetam or any inactive ingredient in BRIVIACT (bronchospasm and angioedema have occurred)
Adverse Reactions
Most common (>=4%) dizziness, somnolence, nausea, headache, diplopia, vomiting, fatigue, vertigo, ataxia, blurred vision, tremor
Serious suicidal behavior and ideation, serious dermatologic reactions, DRESS/multiorgan hypersensitivity, anaphylactic reactions and angioedema, hyponatremia, drug-induced liver injury, abnormal thyroid function, pancytopenia, agranulocytosis, leukopenia
Postmarketing leukopenia, agranulocytosis, thrombocytopenia, megaloblastic anemia, pancytopenia, syndrome of inappropriate antidiuretic hormone secretion (SIADH)
Most common (>=5%) Somnolence and sedation, dizziness, fatigue, nausea and vomiting symptoms
Serious Suicidal behavior and ideation, neurological adverse reactions, psychiatric adverse reactions, hypersensitivity (bronchospasm and angioedema), serious dermatologic reactions, hematologic abnormalities (decreased white blood cell and neutrophil counts)
Postmarketing Serious dermatologic reactions (Stevens-Johnson syndrome and toxic epidermal necrolysis)
Pharmacology
APTIOM is extensively converted to its active metabolite eslicarbazepine after oral administration; eslicarbazepine exerts anticonvulsant activity thought to involve inhibition of voltage-gated sodium channels.
Brivaracetam is an anticonvulsant with high and selective affinity for synaptic vesicle protein 2A (SV2A) in the brain; the precise mechanism by which it exerts anticonvulsant activity is not fully established.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Aptiom
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (0/12) · Qty limit (0/12)
Briviact
- Covered on 5 commercial plans
- PA (12/12) · Step Therapy (3/12) · Qty limit (0/12)
UnitedHealthcare
Aptiom
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (3/8)
Briviact
- Covered on 4 commercial plans
- PA (4/8) · Step Therapy (3/8) · Qty limit (0/8)
Humana
Aptiom
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Briviact
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (2/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
$35/fillfill
Aptiom High-Deductible Discount CardCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
$10/momo
Briviact Patient Savings CardCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.