| Seizures, Focal
Aptiom vs Fycompa
Side-by-side clinical, coverage, and cost comparison for seizures, focal.Deep comparison between: Aptiom vs Fycompa with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsFycompa has a higher rate of injection site reactions vs Aptiom based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Fycompa but not Aptiom, including UnitedHealthcare
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Category
Aptiom
Fycompa
At A Glance
Oral
Once daily
Sodium channel inhibitor
Oral
Once daily
AMPA receptor antagonist
Indications
- Seizures, Focal
- Seizures, Focal
- Tonic-Clonic Epilepsy
Dosing
Seizures, Focal (Adults) Initial 400 mg orally once daily; may initiate at 800 mg once daily if need for seizure reduction outweighs increased adverse reaction risk; increase weekly by 400-600 mg to recommended maintenance of 800-1600 mg once daily.
Seizures, Focal (Pediatric, 4-17 years) Weight-based once daily oral dosing; initial dose and titration increments per weight table; maintenance 400-1200 mg/day depending on body weight range (11-21 kg: 400-600 mg; 22-31 kg: 500-800 mg; 32-38 kg: 600-900 mg; >38 kg: 800-1200 mg).
Renal Impairment (Moderate or Severe) Reduce dosage by 50% in patients with creatinine clearance below 50 mL/min.
Seizures, Focal Start at 2 mg once daily at bedtime; increase by 2 mg no more frequently than weekly; recommended maintenance 8-12 mg once daily at bedtime (monotherapy or adjunctive). With concomitant moderate or strong CYP3A4 inducers, start at 4 mg once daily.
Tonic-Clonic Epilepsy Start at 2 mg once daily at bedtime; increase by 2 mg no more frequently than weekly; recommended maintenance 8 mg once daily at bedtime (adjunctive). With concomitant moderate or strong CYP3A4 inducers, start at 4 mg once daily.
Contraindications
- Hypersensitivity to eslicarbazepine acetate or oxcarbazepine
—
Adverse Reactions
Most common (>=4%) dizziness, somnolence, nausea, headache, diplopia, vomiting, fatigue, vertigo, ataxia, blurred vision, tremor
Serious suicidal behavior and ideation, serious dermatologic reactions, DRESS/multiorgan hypersensitivity, anaphylactic reactions and angioedema, hyponatremia, drug-induced liver injury, abnormal thyroid function, pancytopenia, agranulocytosis, leukopenia
Postmarketing leukopenia, agranulocytosis, thrombocytopenia, megaloblastic anemia, pancytopenia, syndrome of inappropriate antidiuretic hormone secretion (SIADH)
Most common (>=4%) dizziness, somnolence, fatigue, irritability, falls, nausea, ataxia, balance disorder, gait disturbance, vertigo, weight gain
Serious serious psychiatric and behavioral reactions, suicidal behavior and ideation, neurologic effects, falls, DRESS/multiorgan hypersensitivity
Postmarketing DRESS, acute psychosis, hallucinations, delusions, paranoia, delirium, confusional state, disorientation, memory impairment
Pharmacology
APTIOM is extensively converted to its active metabolite eslicarbazepine after oral administration; eslicarbazepine exerts anticonvulsant activity thought to involve inhibition of voltage-gated sodium channels.
Perampanel is a non-competitive antagonist of the ionotropic AMPA glutamate receptor on post-synaptic neurons, reducing neuronal over-excitation caused by glutamate, the primary excitatory neurotransmitter in the CNS; the precise mechanism by which it exerts antiepileptic effects in humans is unknown.
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Most Common Insurance
Anthem BCBS
Aptiom
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (0/12) · Qty limit (0/12)
Fycompa
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (1/12) · Qty limit (9/12)
UnitedHealthcare
Aptiom
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (3/8)
Fycompa
- Covered on 4 commercial plans
- PA (4/8) · Step Therapy (0/8) · Qty limit (2/8)
Humana
Aptiom
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Fycompa
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
$35/fillfill
Aptiom High-Deductible Discount CardCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
$5/momo
Fycompa Instant Savings Card - Covered benefitCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
Final cost depends on formulary coverage
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.