| Seizures, Focal
Aptiom vs Xcopri
Side-by-side clinical, coverage, and cost comparison for seizures, focal.Deep comparison between: Aptiom vs Xcopri with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsXcopri has a higher rate of injection site reactions vs Aptiom based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Xcopri but not Aptiom, including UnitedHealthcare
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Category
Aptiom
Xcopri
At A Glance
Oral
Once daily
Sodium channel inhibitor
Oral
Once daily
Sodium channel inhibitor / GABA-A modulator
Indications
- Seizures, Focal
- Seizures, Focal
Dosing
Seizures, Focal (Adults) Initial 400 mg orally once daily; may initiate at 800 mg once daily if need for seizure reduction outweighs increased adverse reaction risk; increase weekly by 400-600 mg to recommended maintenance of 800-1600 mg once daily.
Seizures, Focal (Pediatric, 4-17 years) Weight-based once daily oral dosing; initial dose and titration increments per weight table; maintenance 400-1200 mg/day depending on body weight range (11-21 kg: 400-600 mg; 22-31 kg: 500-800 mg; 32-38 kg: 600-900 mg; >38 kg: 800-1200 mg).
Renal Impairment (Moderate or Severe) Reduce dosage by 50% in patients with creatinine clearance below 50 mL/min.
Seizures, Focal Initiate at 12.5 mg once daily and titrate every 2 weeks to recommended maintenance dose of 200 mg once daily (oral); maximum 400 mg once daily; for mild to moderate hepatic impairment, maximum 200 mg once daily.
Contraindications
- Hypersensitivity to eslicarbazepine acetate or oxcarbazepine
- Hypersensitivity to cenobamate or any of the inactive ingredients in XCOPRI
- Familial Short QT syndrome
Adverse Reactions
Most common (>=4%) dizziness, somnolence, nausea, headache, diplopia, vomiting, fatigue, vertigo, ataxia, blurred vision, tremor
Serious suicidal behavior and ideation, serious dermatologic reactions, DRESS/multiorgan hypersensitivity, anaphylactic reactions and angioedema, hyponatremia, drug-induced liver injury, abnormal thyroid function, pancytopenia, agranulocytosis, leukopenia
Postmarketing leukopenia, agranulocytosis, thrombocytopenia, megaloblastic anemia, pancytopenia, syndrome of inappropriate antidiuretic hormone secretion (SIADH)
Most common (>=10%) Somnolence, dizziness, fatigue, diplopia, headache
Serious DRESS/multiorgan hypersensitivity, QT shortening, suicidal behavior and ideation, liver injury, neurological adverse reactions
Postmarketing Psychosis (hallucinations, delusions/paranoia), hostility, aggression, hepatic failure
Pharmacology
APTIOM is extensively converted to its active metabolite eslicarbazepine after oral administration; eslicarbazepine exerts anticonvulsant activity thought to involve inhibition of voltage-gated sodium channels.
Cenobamate reduces repetitive neuronal firing by inhibiting voltage-gated sodium currents and is also a positive allosteric modulator of the GABA-A ion channel; the precise mechanism by which these effects translate to seizure reduction in patients with partial-onset seizures is unknown.
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Most Common Insurance
Anthem BCBS
Aptiom
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (0/12) · Qty limit (0/12)
Xcopri
- Covered on 5 commercial plans
- PA (8/12) · Step Therapy (2/12) · Qty limit (11/12)
UnitedHealthcare
Aptiom
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (3/8)
Xcopri
- Covered on 4 commercial plans
- PA (5/8) · Step Therapy (3/8) · Qty limit (2/8)
Humana
Aptiom
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Xcopri
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
$35/fillfill
Aptiom High-Deductible Discount CardCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
$20/momo
Xcopri Coupon CardCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
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AptiomView full Aptiom profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.