| Seizures, Focal
Briviact vs Vimpat
Side-by-side clinical, coverage, and cost comparison for seizures, focal.Deep comparison between: Briviact vs Vimpat with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsVimpat has a higher rate of injection site reactions vs Briviact based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Vimpat but not Briviact, including UnitedHealthcare
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Category
Briviact
Vimpat
At A Glance
Oral; IV infusion
Twice daily
SV2A ligand
Oral; IV infusion
Twice daily
Sodium channel modulator
Indications
- Seizures, Focal
- Seizures, Focal
- Idiopathic generalized epilepsy
Dosing
Seizures, Focal Adults (>=16 years): 50 mg twice daily (range 25-100 mg twice daily); pediatric patients >=50 kg: 25-50 mg twice daily (range 25-100 mg twice daily); pediatric patients <50 kg: weight-based dosing twice daily; IV injection at the same dose when oral administration is temporarily not feasible; dose adjustment required for all stages of hepatic impairment.
Seizures, Focal Monotherapy (adults >=17 years): initiate 100 mg twice daily, maintenance 150-200 mg twice daily (300-400 mg/day); adjunctive therapy (adults): initiate 50 mg twice daily, maintenance 100-200 mg twice daily (200-400 mg/day); pediatric patients 1 month to <17 years: weight-based dosing twice daily; max 200 mg twice daily; IV infusion available at same dose when oral temporarily not feasible.
Idiopathic generalized epilepsy Adjunctive therapy only for patients 4 years of age and older; adults: initiate 50 mg twice daily, titrate by 50 mg twice daily weekly, maintenance 100-200 mg twice daily (200-400 mg/day); pediatric patients: weight-based dosing twice daily.
Contraindications
- Hypersensitivity to brivaracetam or any inactive ingredient in BRIVIACT (bronchospasm and angioedema have occurred)
—
Adverse Reactions
Most common (>=5%) Somnolence and sedation, dizziness, fatigue, nausea and vomiting symptoms
Serious Suicidal behavior and ideation, neurological adverse reactions, psychiatric adverse reactions, hypersensitivity (bronchospasm and angioedema), serious dermatologic reactions, hematologic abnormalities (decreased white blood cell and neutrophil counts)
Postmarketing Serious dermatologic reactions (Stevens-Johnson syndrome and toxic epidermal necrolysis)
Most common (>=2%) dizziness, headache, nausea, diplopia, ataxia, somnolence, vomiting, fatigue, blurred vision, vertigo, tremor, nystagmus, balance disorder
Serious suicidal behavior and ideation, dizziness and ataxia, cardiac rhythm and conduction abnormalities, syncope, DRESS/multiorgan hypersensitivity reactions
Postmarketing agranulocytosis, aggression, agitation, hallucination, insomnia, psychotic disorder, angioedema, rash, urticaria, Stevens-Johnson syndrome, toxic epidermal necrolysis, dyskinesia, new or worsening seizures
Pharmacology
Brivaracetam is an anticonvulsant with high and selective affinity for synaptic vesicle protein 2A (SV2A) in the brain; the precise mechanism by which it exerts anticonvulsant activity is not fully established.
Lacosamide selectively enhances slow inactivation of voltage-gated sodium channels, resulting in stabilization of hyperexcitable neuronal membranes and inhibition of repetitive neuronal firing; it is a functionalized amino acid antiepileptic agent.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Briviact
- Covered on 5 commercial plans
- PA (12/12) · Step Therapy (3/12) · Qty limit (0/12)
Vimpat
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (1/12) · Qty limit (9/12)
UnitedHealthcare
Briviact
- Covered on 4 commercial plans
- PA (4/8) · Step Therapy (3/8) · Qty limit (0/8)
Vimpat
- Covered on 4 commercial plans
- PA (4/8) · Step Therapy (4/8) · Qty limit (1/8)
Humana
Briviact
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (2/3) · Qty limit (0/3)
Vimpat
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
$10/momo
Briviact Patient Savings CardCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
No savings programs available for Vimpat.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.