| Seizures, Focal
Briviact vs Xcopri
Side-by-side clinical, coverage, and cost comparison for seizures, focal.Deep comparison between: Briviact vs Xcopri with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsXcopri has a higher rate of injection site reactions vs Briviact based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Xcopri but not Briviact, including UnitedHealthcare
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Category
Briviact
Xcopri
At A Glance
Oral; IV infusion
Twice daily
SV2A ligand
Oral
Once daily
Sodium channel inhibitor / GABA-A modulator
Indications
- Seizures, Focal
- Seizures, Focal
Dosing
Seizures, Focal Adults (>=16 years): 50 mg twice daily (range 25-100 mg twice daily); pediatric patients >=50 kg: 25-50 mg twice daily (range 25-100 mg twice daily); pediatric patients <50 kg: weight-based dosing twice daily; IV injection at the same dose when oral administration is temporarily not feasible; dose adjustment required for all stages of hepatic impairment.
Seizures, Focal Initiate at 12.5 mg once daily and titrate every 2 weeks to recommended maintenance dose of 200 mg once daily (oral); maximum 400 mg once daily; for mild to moderate hepatic impairment, maximum 200 mg once daily.
Contraindications
- Hypersensitivity to brivaracetam or any inactive ingredient in BRIVIACT (bronchospasm and angioedema have occurred)
- Hypersensitivity to cenobamate or any of the inactive ingredients in XCOPRI
- Familial Short QT syndrome
Adverse Reactions
Most common (>=5%) Somnolence and sedation, dizziness, fatigue, nausea and vomiting symptoms
Serious Suicidal behavior and ideation, neurological adverse reactions, psychiatric adverse reactions, hypersensitivity (bronchospasm and angioedema), serious dermatologic reactions, hematologic abnormalities (decreased white blood cell and neutrophil counts)
Postmarketing Serious dermatologic reactions (Stevens-Johnson syndrome and toxic epidermal necrolysis)
Most common (>=10%) Somnolence, dizziness, fatigue, diplopia, headache
Serious DRESS/multiorgan hypersensitivity, QT shortening, suicidal behavior and ideation, liver injury, neurological adverse reactions
Postmarketing Psychosis (hallucinations, delusions/paranoia), hostility, aggression, hepatic failure
Pharmacology
Brivaracetam is an anticonvulsant with high and selective affinity for synaptic vesicle protein 2A (SV2A) in the brain; the precise mechanism by which it exerts anticonvulsant activity is not fully established.
Cenobamate reduces repetitive neuronal firing by inhibiting voltage-gated sodium currents and is also a positive allosteric modulator of the GABA-A ion channel; the precise mechanism by which these effects translate to seizure reduction in patients with partial-onset seizures is unknown.
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Most Common Insurance
Anthem BCBS
Briviact
- Covered on 5 commercial plans
- PA (12/12) · Step Therapy (3/12) · Qty limit (0/12)
Xcopri
- Covered on 5 commercial plans
- PA (8/12) · Step Therapy (2/12) · Qty limit (11/12)
UnitedHealthcare
Briviact
- Covered on 4 commercial plans
- PA (4/8) · Step Therapy (3/8) · Qty limit (0/8)
Xcopri
- Covered on 4 commercial plans
- PA (5/8) · Step Therapy (3/8) · Qty limit (2/8)
Humana
Briviact
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (2/3) · Qty limit (0/3)
Xcopri
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
$10/momo
Briviact Patient Savings CardCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
$20/momo
Xcopri Coupon CardCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.