| Sleep Apnea, Obstructive
Sunosi vs Nuvigil
Side-by-side clinical, coverage, and cost comparison for sleep apnea, obstructive.Deep comparison between: Sunosi vs Nuvigil with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsNuvigil has a higher rate of injection site reactions vs Sunosi based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Nuvigil but not Sunosi, including UnitedHealthcare
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Category
Sunosi
Nuvigil
At A Glance
Oral
Once daily
DNRI
Oral
Once daily
Wakefulness-promoting agent
Indications
- Narcolepsy
- Sleep Apnea, Obstructive
- Sleep Apnea, Obstructive
- Narcolepsy
- Shift work disorder
Dosing
Narcolepsy 75 mg orally once daily upon awakening; may double every 3 days based on efficacy and tolerability; maximum 150 mg once daily.
Sleep Apnea, Obstructive 37.5 mg orally once daily upon awakening; may double every 3 days based on efficacy and tolerability; maximum 150 mg once daily.
Renal Impairment Moderate (eGFR 30-59 mL/min/1.73 m2): start 37.5 mg once daily, may increase to max 75 mg after at least 7 days. Severe (eGFR 15-29 mL/min/1.73 m2): 37.5 mg once daily; maximum 37.5 mg. ESRD: not recommended.
Sleep Apnea, Obstructive, Narcolepsy 150 mg to 250 mg taken orally once daily as a single dose in the morning.
Shift work disorder 150 mg taken orally once daily as a single dose approximately 1 hour prior to the start of the work shift.
Contraindications
- Concomitant use with MAO inhibitors or within 14 days after discontinuing MAOI treatment due to risk of hypertensive reaction
- Known hypersensitivity to modafinil or armodafinil or its inactive ingredients
Adverse Reactions
Most common (>=5%) headache, nausea, decreased appetite, anxiety, insomnia
Serious blood pressure and heart rate increases, psychiatric symptoms
Postmarketing hypersensitivity reactions (rash erythematous, rash, urticaria)
Most common (>=5%) Headache, nausea, dizziness, insomnia
Serious Serious dermatologic reactions, DRESS/multiorgan hypersensitivity, angioedema and anaphylaxis, persistent sleepiness, psychiatric symptoms, cardiovascular events
Postmarketing Mouth sores (including mouth blistering and ulceration)
Pharmacology
Solriamfetol is a dopamine and norepinephrine reuptake inhibitor (DNRI) that inhibits reuptake of dopamine and norepinephrine with no appreciable binding to serotonin transporters or to dopamine, serotonin, norepinephrine, GABA, adenosine, histamine, orexin, or acetylcholine receptors.
Armodafinil is a wakefulness-promoting agent and indirect dopamine receptor agonist that binds to the dopamine transporter and inhibits dopamine reuptake, with wake-promoting actions similar to sympathomimetic agents, although its precise mechanism is unknown.
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Most Common Insurance
Anthem BCBS
Sunosi
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (1/12)
Nuvigil
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (10/12)
UnitedHealthcare
Sunosi
- Covered on 4 commercial plans
- PA (7/8) · Step Therapy (6/8) · Qty limit (7/8)
Nuvigil
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Sunosi
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (3/3)
Nuvigil
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAssistance Fund: Narcolepsy
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
No savings programs available for Nuvigil.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.