| Stable angina
Lipitor vs Norliqva
Side-by-side clinical, coverage, and cost comparison for stable angina.Deep comparison between: Lipitor vs Norliqva with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsNorliqva has a higher rate of injection site reactions vs Lipitor based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Norliqva but not Lipitor, including UnitedHealthcare
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Category
Lipitor
Norliqva
At A Glance
Oral
Daily
HMG-CoA reductase inhibitor (statin)
Oral
Daily
Calcium channel blocker
Indications
- Myocardial Infarction
- Cerebrovascular accident
- Stable angina
- Diabetes Mellitus, Non-Insulin-Dependent
- Congestive heart failure
- Hyperlipidemia
- Familial hypercholesterolemia - heterozygous
- Homozygous Familial Hypercholesterolemia
- Hyperlipoproteinemia Type III
- Hypertriglyceridemia
- Hypertensive disease
- Stable angina
- Coronary heart disease
Dosing
Myocardial Infarction, Cerebrovascular accident, Stable angina, Diabetes Mellitus Non-Insulin-Dependent, Congestive heart failure, Hyperlipidemia, Hyperlipoproteinemia Type III, Hypertriglyceridemia 10 or 20 mg once daily starting; range 10-80 mg once daily; patients requiring LDL-C reduction >45% may start at 40 mg once daily; oral.
Familial hypercholesterolemia - heterozygous Adults: 10 or 20 mg once daily, range 10-80 mg once daily; pediatric patients aged >=10 years: 10 mg once daily starting, range 10-20 mg once daily; oral.
Homozygous Familial Hypercholesterolemia Adults: 10 or 20 mg once daily, range 10-80 mg once daily; pediatric patients aged >=10 years: 10-20 mg once daily starting, range 10-80 mg once daily; oral.
Hypertensive disease Adults: 5 mg orally once daily (max 10 mg); small, fragile, elderly, or hepatic insufficiency patients start at 2.5 mg once daily; pediatric patients (>=6 years): 2.5-5 mg orally once daily.
Stable angina 5-10 mg orally once daily; most patients require 10 mg for adequate effect.
Coronary heart disease 5-10 mg orally once daily; majority of patients in clinical studies required 10 mg.
Contraindications
- Acute liver failure or decompensated cirrhosis
- Hypersensitivity to atorvastatin or any excipient in Lipitor
- Known sensitivity to amlodipine
Adverse Reactions
Most common (>=2%) Nasopharyngitis, arthralgia, diarrhea, pain in extremity, urinary tract infection, dyspepsia, nausea, musculoskeletal pain, muscle spasms, myalgia, insomnia, pharyngolaryngeal pain
Serious Myopathy and rhabdomyolysis, immune-mediated necrotizing myopathy, hepatic dysfunction, increases in HbA1c and fasting serum glucose
Postmarketing Pancreatitis, fatigue, fatal and non-fatal hepatic failure, anaphylaxis, tendon rupture, rhabdomyolysis, myositis, dizziness, peripheral neuropathy, cognitive impairment, myasthenia gravis exacerbation, depression, interstitial lung disease, angioneurotic edema, bullous rashes
Most common (>1%) Edema, dizziness, flushing, palpitation, fatigue, nausea.
Postmarketing Gynecomastia, jaundice, hepatic enzyme elevations, extrapyramidal disorder.
Pharmacology
Lipitor is a selective, competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl-coenzyme A to mevalonate, a precursor of cholesterol; it lowers plasma LDL cholesterol and lipoprotein levels by inhibiting hepatic cholesterol synthesis and upregulating LDL receptor expression on hepatic cell surfaces.
Amlodipine is a dihydropyridine calcium channel blocker that inhibits transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle, acting as a peripheral arterial vasodilator to reduce peripheral vascular resistance and blood pressure, and relieving angina by reducing myocardial oxygen demand and blocking coronary vasospasm.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Lipitor
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (5/12) · Qty limit (1/12)
Norliqva
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (0/12) · Qty limit (6/12)
UnitedHealthcare
Lipitor
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Norliqva
- Covered on 4 commercial plans
- PA (4/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Lipitor
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (1/3)
Norliqva
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (2/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Lipitor.
No savings programs available for Norliqva.
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LipitorView full Lipitor profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.