| Thyroid carcinoma
Retevmo vs Tirosint
Side-by-side clinical, coverage, and cost comparison for thyroid carcinoma.Deep comparison between: Retevmo vs Tirosint with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsTirosint has a higher rate of injection site reactions vs Retevmo based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Tirosint but not Retevmo, including UnitedHealthcare
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Category
Retevmo
Tirosint
At A Glance
Oral
Twice daily
RET kinase inhibitor
Oral
Daily
Thyroid hormone replacement
Indications
- Non-Small Cell Lung Carcinoma
- Medullary carcinoma of thyroid
- Thyroid carcinoma
- Hypothyroidism
- Thyroid carcinoma
Dosing
Non-Small Cell Lung Carcinoma, Medullary carcinoma of thyroid, Thyroid carcinoma Adults and adolescents >= 12 years: 120 mg orally twice daily (< 50 kg) or 160 mg orally twice daily (>= 50 kg); pediatric patients 2 to < 12 years: 40 mg three times daily to 160 mg twice daily orally based on body surface area; administered until disease progression or unacceptable toxicity.
Hypothyroidism Average full replacement dose approximately 1.6 mcg/kg/day orally once daily on an empty stomach, one-half to one hour before breakfast; dose individualized by age, body weight, cardiovascular status, and clinical response; adjust by 12.5 to 25 mcg increments every 4 to 6 weeks; elderly or cardiovascular patients start at 12.5 to 25 mcg/day.
Thyroid carcinoma TSH generally suppressed to below 0.1 mIU/L; usually requires TIROSINT dose greater than 2 mcg/kg/day; target TSH suppression level may be lower in high-risk tumors.
Contraindications
—
- Uncorrected adrenal insufficiency
Adverse Reactions
Most common (>=25%) edema, diarrhea, fatigue, dry mouth, hypertension, abdominal pain, constipation, rash, nausea, headache
Serious hepatotoxicity, interstitial lung disease/pneumonitis, hypertension, QT interval prolongation, hemorrhagic events, hypersensitivity, tumor lysis syndrome, impaired wound healing, hypothyroidism, slipped capital femoral epiphysis in adolescents
Postmarketing Stevens-Johnson Syndrome
Most common Fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating, headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia, tremors, muscle weakness, muscle spasm, palpitations, tachycardia, dyspnea, diarrhea, vomiting, abdominal cramps, elevated liver function tests, hair loss, flushing, rash, decreased bone mineral density, menstrual irregularities, impaired fertility
Serious Arrhythmias, increased pulse and blood pressure, heart failure, angina, myocardial infarction, cardiac arrest, seizures (rare), pseudotumor cerebri and slipped capital femoral epiphysis in children, craniosynostosis in infants, premature closure of epiphyses in children
Hypersensitivity Urticaria, pruritus, skin rash, flushing, angioedema, abdominal pain, nausea, vomiting, diarrhea, fever, arthralgia, serum sickness, wheezing (reactions to inactive ingredients)
Pharmacology
Selpercatinib is a kinase inhibitor that selectively inhibits wild-type RET and multiple mutated RET isoforms (including gene fusions and activating point mutations) as well as VEGFR1 and VEGFR3, and at clinically achievable concentrations also inhibits FGFR1, 2, and 3, blocking constitutive RET signaling that acts as an oncogenic driver promoting tumor cell proliferation.
Synthetic levothyroxine (T4) that exerts the same physiologic effect as endogenous T4; thyroid hormones control DNA transcription and protein synthesis by diffusing into the cell nucleus and binding thyroid receptor proteins attached to DNA, with physiological actions produced predominantly by T3, approximately 80% of which is derived from T4 by peripheral deiodination.
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Most Common Insurance
Anthem BCBS
No coverage data available for Retevmo.
Tirosint
- Covered on 5 commercial plans
- PA (3/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Retevmo
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (6/8)
Tirosint
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Retevmo
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Tirosint
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Retevmo.
No savings programs available for Tirosint.
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RetevmoView full Retevmo profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.