| Thyroid carcinoma
Tirosint SOL vs Tirosint
Side-by-side clinical, coverage, and cost comparison for thyroid carcinoma.Deep comparison between: Tirosint vs Tirosint with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsTirosint has a higher rate of injection site reactions vs Tirosint based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Tirosint but not Tirosint, including UnitedHealthcare
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Category
Tirosint
Tirosint
At A Glance
Oral
Daily
Thyroid hormone (synthetic T4)
Oral
Daily
Thyroid hormone replacement
Indications
- Hypothyroidism
- Thyroid carcinoma
- Hypothyroidism
- Thyroid carcinoma
Dosing
Hypothyroidism Once daily oral dose on empty stomach, 15 minutes before breakfast; adults start at 1.6 mcg/kg/day (lower in cardiac or geriatric patients), titrate by 12.5-25 mcg every 4-6 weeks; pediatric dosing weight-based by age (1.6-15 mcg/kg/day), titrated every 2 weeks; pregnant patients may require increased dose monitored every 4 weeks.
Thyroid carcinoma Once daily oral dose; dosage based on target level of TSH suppression for the stage and clinical status of well-differentiated thyroid cancer.
Hypothyroidism Average full replacement dose approximately 1.6 mcg/kg/day orally once daily on an empty stomach, one-half to one hour before breakfast; dose individualized by age, body weight, cardiovascular status, and clinical response; adjust by 12.5 to 25 mcg increments every 4 to 6 weeks; elderly or cardiovascular patients start at 12.5 to 25 mcg/day.
Thyroid carcinoma TSH generally suppressed to below 0.1 mIU/L; usually requires TIROSINT dose greater than 2 mcg/kg/day; target TSH suppression level may be lower in high-risk tumors.
Contraindications
- Hypersensitivity to glycerol (inactive ingredient in TIROSINT-SOL)
- Uncorrected adrenal insufficiency
- Uncorrected adrenal insufficiency
Adverse Reactions
Most common Fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating, headache, hyperactivity, nervousness, anxiety, irritability, insomnia, tremors, muscle weakness, palpitations, tachycardia, diarrhea, vomiting, abdominal cramps, hair loss, flushing, rash, decreased bone mineral density, menstrual irregularities, impaired fertility
Serious Arrhythmias, increased blood pressure, heart failure, angina, myocardial infarction, cardiac arrest, seizures (rare); pseudotumor cerebri and slipped capital femoral epiphysis in pediatric patients
Hypersensitivity Urticaria, pruritus, skin rash, flushing, angioedema, abdominal pain, nausea, vomiting, diarrhea, fever, arthralgia, serum sickness, wheezing
Most common Fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating, headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia, tremors, muscle weakness, muscle spasm, palpitations, tachycardia, dyspnea, diarrhea, vomiting, abdominal cramps, elevated liver function tests, hair loss, flushing, rash, decreased bone mineral density, menstrual irregularities, impaired fertility
Serious Arrhythmias, increased pulse and blood pressure, heart failure, angina, myocardial infarction, cardiac arrest, seizures (rare), pseudotumor cerebri and slipped capital femoral epiphysis in children, craniosynostosis in infants, premature closure of epiphyses in children
Hypersensitivity Urticaria, pruritus, skin rash, flushing, angioedema, abdominal pain, nausea, vomiting, diarrhea, fever, arthralgia, serum sickness, wheezing (reactions to inactive ingredients)
Pharmacology
Synthetic T4 hormone (levothyroxine sodium) that exerts physiologic effects through control of DNA transcription and protein synthesis by binding thyroid receptor proteins attached to DNA in cell nuclei; the predominant active form T3 is derived approximately 80% from peripheral deiodination of T4, and oral levothyroxine maintains normal T4 levels when endogenous production is deficient.
Synthetic levothyroxine (T4) that exerts the same physiologic effect as endogenous T4; thyroid hormones control DNA transcription and protein synthesis by diffusing into the cell nucleus and binding thyroid receptor proteins attached to DNA, with physiological actions produced predominantly by T3, approximately 80% of which is derived from T4 by peripheral deiodination.
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Most Common Insurance
Anthem BCBS
Tirosint
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (0/12)
Tirosint
- Covered on 5 commercial plans
- PA (3/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Tirosint
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (0/8)
Tirosint
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Tirosint
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (0/3) · Qty limit (0/3)
Tirosint
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Tirosint.
No savings programs available for Tirosint.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.