| Urinary tract infection
Doryx MPC vs Zemdri
Side-by-side clinical, coverage, and cost comparison for urinary tract infection.Deep comparison between: Doryx Mpc vs Zemdri (Plazomicin) with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsZemdri (Plazomicin) has a higher rate of injection site reactions vs Doryx Mpc based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Zemdri (Plazomicin) but not Doryx Mpc, including UnitedHealthcare
Sign up to reveal the full AI analysis
Category
Doryx Mpc
Zemdri (Plazomicin)
At A Glance
Oral
Once or twice daily
Tetracycline antibiotic
IV infusion
Every 24 hours
Aminoglycoside
Indications
- Rocky Mountain Spotted Fever
- TYPHUS
- Q Fever
- Rickettsialpox
- non-gonococcal urethritis (NGU)
- Lymphogranuloma Venereum
- Granuloma Inguinale
- Gonorrhea
- Chancroid
- Psittacosis
- Respiratory Tract Infections
- Upper Respiratory Infections
- Relapsing Fever
- Plague
- Tularemia
- Cholera
- Brucellosis
- Bartonella Infections
- Trachoma
- Inclusion conjunctivitis
- Anthrax disease
- Syphilis
- Yaws
- Listeriosis
- Necrotizing Ulcerative Gingivitis
- Actinomycosis
- Amebiasis
- Acne Vulgaris
- Malaria
- Urethritis
- Uterine Cervicitis
- Proctitis
- Urinary tract infection
- Urinary tract infection
Dosing
Rocky Mountain Spotted Fever, TYPHUS, Q Fever, Rickettsialpox, Relapsing Fever, Plague, Tularemia, Cholera, Brucellosis, Bartonella Infections, Psittacosis, Respiratory Tract Infections, Upper Respiratory Infections, Trachoma, Inclusion conjunctivitis, Yaws, Listeriosis, Necrotizing Ulcerative Gingivitis, Actinomycosis, Amebiasis, Acne Vulgaris, Urinary tract infection Adults: 240 mg on day 1 (120 mg every 12 hours), then 120 mg daily maintenance; for severe infections (e.g., chronic urinary tract infections), 120 mg every 12 hours. Pediatric <45 kg (>8 years, less severe disease): 5.3 mg/kg divided in 2 doses on day 1, then 2.6 mg/kg daily; severe or life-threatening infections: 2.6 mg/kg every 12 hours. Pediatric >=45 kg: adult dose.
non-gonococcal urethritis (NGU), Urethritis, Uterine Cervicitis, Proctitis 120 mg orally twice daily for 7 days.
Gonorrhea 120 mg orally twice daily for 7 days; alternate single-visit dose: 360 mg followed in 1 hour by a second 360 mg dose.
Syphilis (early, penicillin allergy) 120 mg orally twice daily for 2 weeks.
Syphilis (>1 year duration, penicillin allergy) 120 mg orally twice daily for 4 weeks.
Anthrax disease Adults: 120 mg orally twice daily for 60 days. Pediatric <45 kg: 2.6 mg/kg orally twice daily for 60 days; >=45 kg: adult dose.
Malaria Adults: 120 mg once daily. Pediatric >=8 years: 2.4 mg/kg once daily; >=45 kg: adult dose. Begin 1-2 days before travel, continue during travel, and for 4 weeks after leaving the malarious area.
Urinary tract infection 15 mg/kg every 24 hours by IV infusion over 30 minutes for 4 to 7 days in adults with CLcr >=90 mL/min; dose reduced to 10 mg/kg every 24 hours (CLcr 30 to <90 mL/min) or 10 mg/kg every 48 hours (CLcr 15 to <30 mL/min).
Contraindications
- Hypersensitivity to any of the tetracyclines
- Known hypersensitivity to any aminoglycoside
Adverse Reactions
Gastrointestinal Anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, pancreatitis, esophagitis, esophageal ulcerations
Skin Maculopapular rashes, erythematous rashes, Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, erythema multiforme, fixed drug eruption, photosensitivity
Hypersensitivity Urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, serum sickness, pericarditis, exacerbation of systemic lupus erythematosus
Hematologic Hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia
Neurologic/Psychiatric Intracranial hypertension (pseudotumor cerebri), depression, anxiety, suicidal ideation, insomnia, abnormal dreams, hallucination
Renal Rise in BUN (dose-related)
Thyroid Brown-black microscopic discoloration of thyroid glands with prolonged use; no known thyroid function abnormalities
Most common (>=1%) Decreased renal function, diarrhea, hypertension, headache, nausea, vomiting, hypotension
Serious Nephrotoxicity, ototoxicity, neuromuscular blockade, fetal harm, hypersensitivity reactions, Clostridium difficile-associated diarrhea
Pharmacology
Doxycycline is a tetracycline-class antimicrobial that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, exerting bacteriostatic activity against a broad range of Gram-positive and Gram-negative bacteria.
Plazomicin is an aminoglycoside antibacterial that binds to the bacterial 30S ribosomal subunit, inhibiting protein synthesis with concentration-dependent bactericidal activity against Enterobacteriaceae.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Doryx Mpc
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (9/12) · Qty limit (0/12)
Zemdri (Plazomicin)
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (5/12) · Qty limit (0/12)
UnitedHealthcare
Doryx Mpc
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (6/8) · Qty limit (0/8)
Zemdri (Plazomicin)
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Doryx Mpc
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Zemdri (Plazomicin)
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Doryx Mpc.
No savings programs available for Zemdri (Plazomicin).
Compare Other Drugs
Let us handle your prior authsJust enter your patient's info and we'll:
- Verify eligibility with the payer.
- Pull the right PA forms directly from the payer.
- Submit, track & send live updates to your dashboard.
Free to start · HIPAA compliant
Next Steps for Your Patient
Doryx MpcView full Doryx Mpc profile
Zemdri (Plazomicin)View full Zemdri (Plazomicin) profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.