| Urinary tract infection
Zemdri vs Targadox
Side-by-side clinical, coverage, and cost comparison for urinary tract infection.Deep comparison between: Zemdri (Plazomicin) vs Targadox with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsTargadox has a higher rate of injection site reactions vs Zemdri (Plazomicin) based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Targadox but not Zemdri (Plazomicin), including UnitedHealthcare
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Category
Zemdri (Plazomicin)
Targadox
At A Glance
IV infusion
Every 24 hours
Aminoglycoside
Oral
Daily to twice daily
Tetracycline antibiotic
Indications
- Urinary tract infection
- Rocky Mountain Spotted Fever
- TYPHUS
- Q Fever
- Rickettsialpox
- Respiratory Tract Infections
- Respiratory Tract Infections
- Upper Respiratory Infections
- Urinary tract infection
- Lymphogranuloma Venereum
- Psittacosis
- Trachoma
- Inclusion conjunctivitis
- Urethritis
- Uterine Cervicitis
- Proctitis
- non-gonococcal urethritis (NGU)
- Relapsing Fever
- Chancroid
- Plague
- Tularemia
- Cholera
- Campylobacter infection
- Brucellosis
- Bartonella Infections
- Granuloma Inguinale
- Anthrax disease
- Gonorrhea
- Syphilis
- Yaws
- Listeriosis
- Necrotizing Ulcerative Gingivitis
- Actinomycosis
- Clostridium Infections
- Amebiasis
- Acne Vulgaris
- Malaria
Dosing
Urinary tract infection 15 mg/kg every 24 hours by IV infusion over 30 minutes for 4 to 7 days in adults with CLcr >=90 mL/min; dose reduced to 10 mg/kg every 24 hours (CLcr 30 to <90 mL/min) or 10 mg/kg every 48 hours (CLcr 15 to <30 mL/min).
Adults (general infections) 200 mg on day 1 (100 mg every 12 hours), then 100 mg/day maintenance; 100 mg every 12 hours for severe or chronic Urinary tract infection.
Pediatric patients <45 kg (severe infections) 2.2 mg/kg every 12 hours; for less severe disease (>8 years, <45 kg): 4.4 mg/kg divided into two doses on day 1, then 2.2 mg/kg/day as a single or divided dose. Children >=45 kg receive the adult dose.
Gonorrhea 100 mg twice daily for 7 days; alternate single-visit dose: 300 mg followed by 300 mg 1 hour later, may be taken with food or beverage.
Urethritis, Uterine Cervicitis, Proctitis, non-gonococcal urethritis (NGU) 100 mg twice daily for 7 days.
Syphilis (early, penicillin-allergic patients) 100 mg twice daily for 2 weeks.
Syphilis (>1 year duration, penicillin-allergic patients) 100 mg twice daily for 4 weeks.
Malaria (prophylaxis) Adults: 100 mg once daily beginning 1-2 days before travel, continuing during travel, and for 4 weeks after leaving the malarious area. Pediatric patients >8 years: 2 mg/kg once daily up to the adult dose.
Anthrax disease (inhalational, post-exposure) Adults: 100 mg twice daily for 60 days. Children <45 kg: 2.2 mg/kg twice daily for 60 days; children >=45 kg receive the adult dose.
Contraindications
- Known hypersensitivity to any aminoglycoside
- Hypersensitivity to any of the tetracyclines
Adverse Reactions
Most common (>=1%) Decreased renal function, diarrhea, hypertension, headache, nausea, vomiting, hypotension
Serious Nephrotoxicity, ototoxicity, neuromuscular blockade, fetal harm, hypersensitivity reactions, Clostridium difficile-associated diarrhea
Most common Nausea, vomiting, diarrhea, anorexia, glossitis, dysphagia, enterocolitis, maculopapular and erythematous rashes.
Serious Toxic epidermal necrolysis, Stevens-Johnson syndrome, anaphylaxis, anaphylactoid purpura, DRESS, intracranial hypertension, hemolytic anemia, thrombocytopenia, hepatotoxicity, esophagitis, esophageal ulceration, permanent tooth discoloration.
Pharmacology
Plazomicin is an aminoglycoside antibacterial that binds to the bacterial 30S ribosomal subunit, inhibiting protein synthesis with concentration-dependent bactericidal activity against Enterobacteriaceae.
Tetracycline-class antibacterial; doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, exhibiting bacteriostatic activity against a broad range of Gram-positive and Gram-negative bacteria.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Zemdri (Plazomicin)
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (5/12) · Qty limit (0/12)
Targadox
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (9/12) · Qty limit (10/12)
UnitedHealthcare
Zemdri (Plazomicin)
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Targadox
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Zemdri (Plazomicin)
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Targadox
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (2/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Zemdri (Plazomicin).
No savings programs available for Targadox.
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Zemdri (Plazomicin)View full Zemdri (Plazomicin) profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.