| Uveitis

Ozurdex vs Purified Cortrophin Gel

Side-by-side clinical, coverage, and cost comparison for uveitis.

Deep comparison between: Ozurdex vs Purified Cortrophin Gel with Prescriber.AI

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Safety signalsPurified Cortrophin Gel has a higher rate of injection site reactions vs Ozurdex based on FDA-approved prescribing information

Coverage gaps3 major payers require step therapy for Purified Cortrophin Gel but not Ozurdex, including UnitedHealthcare

Category

Ozurdex

Purified Cortrophin Gel

At A Glance

RouteIntravitreal injection

ClassCorticosteroid

RouteSC/IM injection

ClassCorticotropin (ACTH)

Indications

Macular retinal edema
Uveitis

Arthritis, Psoriatic
Rheumatoid Arthritis
Ankylosing spondylitis
Primary gout
Lupus Erythematosus, Systemic
Polymyositis
Stevens-Johnson Syndrome
Psoriasis
Dermatitis, Atopic
Serum Sickness
Allergic Conjunctivitis
Keratitis
Iritis
Iridocyclitis
Uveitis
Optic Neuritis
Chorioretinitis
Sarcoidosis
Nephrotic Syndrome
Multiple Sclerosis

Dosing

Macular retinal edema, Uveitis One 0.7 mg intravitreal implant injected into the vitreous cavity under controlled aseptic conditions; each applicator is single-use and treats one eye only.

Arthritis, Psoriatic, Rheumatoid Arthritis, Ankylosing spondylitis, Primary gout, Lupus Erythematosus, Systemic, Polymyositis, Stevens-Johnson Syndrome, Psoriasis, Dermatitis, Atopic, Serum Sickness, Allergic Conjunctivitis, Keratitis, Iritis, Iridocyclitis, Uveitis, Optic Neuritis, Chorioretinitis, Sarcoidosis, Nephrotic Syndrome Dose individualized based on disease severity, plasma and urine corticosteroid levels, and patient response; administer SC or IM; verify adrenal responsiveness prior to treatment (up to 80 units as a single injection); chronic doses above 40 units daily associated with uncontrollable adverse effects.

Multiple Sclerosis 80-120 units daily SC or IM for 2-3 weeks for acute exacerbations.

Contraindications

Active or suspected ocular or periocular infections, including viral diseases of the cornea and conjunctiva (active epithelial herpes simplex keratitis, vaccinia, varicella), mycobacterial infections, and fungal diseases
Glaucoma with cup to disc ratios greater than 0.8
Torn or ruptured posterior lens capsule due to risk of migration into the anterior chamber
Known hypersensitivity to any components of this product

Intravenous administration
Scleroderma
Osteoporosis
Systemic fungal infections
Ocular herpes simplex
Recent surgery
History of or presence of a peptic ulcer
Congestive heart failure
Hypertension
Sensitivity to proteins derived from porcine sources
Primary adrenocortical insufficiency
Adrenocortical hyperfunction

Drug Interactions

1320View drug interactions

648View drug interactions

Adverse Reactions

Most common (>=20%) Cataract, increased intraocular pressure, conjunctival hemorrhage

Serious Elevated IOP with optic nerve damage, visual acuity and field defects, posterior subcapsular cataract formation, secondary ocular infection (including herpes simplex), globe perforation

Postmarketing Endophthalmitis, retinal detachment, implant misplacement with ocular tissue injury, device dislocation with corneal edema or decompensation, hypotony of the eye

Fluid and Electrolyte Sodium retention, hypokalemic alkalosis, fluid retention, calcium loss, potassium loss

Musculoskeletal Muscle weakness, loss of muscle mass, steroid myopathy, osteoporosis, vertebral compression fractures, aseptic necrosis of femoral and humeral heads, pathologic fracture of long bones

Gastrointestinal Peptic ulcer with possible perforation and hemorrhage, abdominal distention, ulcerative esophagitis, pancreatitis

Dermatologic Injection site reactions, impaired wound healing, increased sweating, thin fragile skin, suppression of skin test reactions, petechiae and ecchymoses, acne, hyperpigmentation, facial erythema

Cardiovascular Hypertension, congestive heart failure, necrotizing angiitis

Neurological Convulsions, increased intracranial pressure with papilledema, headache, vertigo

Endocrine Menstrual irregularities, Cushingoid state, suppression of growth in children, secondary adrenocortical and pituitary insufficiency, decreased carbohydrate tolerance, manifestations of latent diabetes mellitus, increased requirements for insulin or oral hypoglycemic agents, hirsutism

Ophthalmic Posterior subcapsular cataracts, increased intraocular pressure, glaucoma with possible damage to optic nerve, exophthalmos

Metabolic Negative nitrogen balance due to protein catabolism

Allergic Dizziness, nausea and vomiting, skin reactions, anaphylaxis (anaphylactic shock, urticaria, respiratory compromise, edema)

Miscellaneous Weight gain, abscess, development of antibodies and loss of stimulatory effect

Pharmacology

Dexamethasone is a corticosteroid that suppresses inflammation by inhibiting multiple inflammatory cytokines, resulting in decreased edema, fibrin deposition, capillary leakage, and migration of inflammatory cells.

Purified Cortrophin Gel is an anterior pituitary hormone (corticotropin/ACTH) that stimulates the functioning adrenal cortex to produce and secrete adrenocortical hormones; it is formulated as a porcine-derived purified ACTH in a sterile gelatin solution for prolonged activity.

View Full FDA Information

View full FDA information

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Most Common Insurance

Anthem BCBS

Ozurdex