Adrenalin (epinephrine In Sodium Chloride)
(Epinephrine In Sodium Chloride)Adrenalin (Epinephrine In Sodium Chloride) Prescribing Information
Injection: Epinephrine in sodium chloride is a clear, colorless solution in a ready-to-use, single-dose container available as:
- 2 mg/250mL (8 mcg/mL)
- 4 mg/250mL (16 mcg/mL)
- 5 mg/250mL (20 mcg/mL)
- 8 mg/250mL (32 mcg/mL)
- 10 mg/250mL (40 mcg/mL)
None.
The following adverse reactions are discussed elsewhere in labeling:
- Hypertension [see Warnings and Precautions ]
- Pulmonary Edema [see Warnings and Precautions ]
- Cardiac Arrhythmias and Ischemia [see Warnings and Precautions ]
- Extravasation and Tissue Necrosis with Intravenous Infusion [see Warnings and Precautions ]
- Renal Impairment [see Warnings and Precautions ]
The following adverse reactions associated with the infusion of epinephrine were identified in the literature. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency reliably or to establish a causal relationship to drug exposure.
Adrenalin (epinephrine in sodium chloride injection) is a sympathomimetic catecholamine. The chemical name of epinephrine is: 1,2- Benzenediol, 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]-, or (-)-3,4-Dihydroxy-α-[2- (methylamino)ethyl]benzyl alcohol.
The chemical structure of epinephrine is:
The molecular weight of epinephrine is 183.2.
Epinephrine solution deteriorates rapidly on exposure to air or light, turning pink from oxidation to adrenochrome and brown from the formation of melanin.
Adrenalin (epinephrine in sodium chloride injection) is a clear, colorless, sterile solution administered by intravenous infusion, supplied in a 250 mL infusion bag. It is provided in five (5) ready-to-use concentrations containing:
| Ingredient | Concentration | ||||
| 8 mcg/mL | 16 mcg/mL | 20 mcg/mL | 32 mcg/mL | 40 mcg/mL | |
| Epinephrine, USP | 8 mcg | 16 mcg | 20 mcg | 32 mcg | 40 mcg |
| Sodium chloride, USP | 9 mg | 9 mg | 9 mg | 9 mg | 9 mg |
| Disodium Edetate Dihydrate (EDTA), USP | 10 mcg | 10 mcg | 10 mcg | 10 mcg | 10 mcg |
| L (+) Tartaric Acid, NF | 6.6 mcg | 13.1 mcg | 16.4 mcg | 26.2 mcg | 32.8 mcg |
It may contain hydrochloric acid and/or sodium hydroxide for pH adjustment. It has a pH range of 3.7 - 4.3. The headspace in the containers has been displaced with nitrogen gas.
Adrenalin (epinephrine in sodium chloride injection) is supplied as a clear, colorless sterile solution in a single-dose 250 mL non-PVC infusion bag with a single function connector system consisting of a port and cap, packaged individually in an aluminum overwrap with an oxygen scavenger.
Supplied as:
Unit of Sale | Strength | Pack Factor |
| NDC 42023-273-10 | 2 mg/250 mL (8 mcg/mL) | 10 units |
| NDC 42023-315-10 | 4 mg/250 mL (16 mcg/mL) | 10 units |
| NDC 42023-434-10 | 5 mg/250 mL (20 mcg/mL) | 10 units |
| NDC 42023-500-10 | 8 mg/250 mL (32 mcg/mL) | 10 units |
| NDC 42023-721-10 | 10 mg/250 mL (40 mcg/mL) | 10 units |
Store between 20°C to 25°C (68°F to 77°F) [
Keep in foil overwrap until ready to use. Discard after 24 hours of opening overwrap.
Manufactured for:
Endo USA
Malvern, PA 19355
© 2024 Endo, Inc. or one of its affiliates.
Revised: 04/2024
Epinephrine acts on both alpha and beta-adrenergic receptors. The mechanism of the rise in blood pressure is 3-fold: a direct myocardial stimulation that increases the strength of ventricular contraction (positive inotropic action), an increased heart rate (positive chronotropic action), and peripheral vasoconstriction.