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Check Drug InteractionsCelecoxib Prescribing Information
Cardiovascular Risk
- Celecoxibmay cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. All nonsteroidal anti-inflammatory drugs (NSAIDs) may have a similar risk. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk(5.1, 14.6).
- Celecoxibis contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery(4, 5.1).
Gastrointestinal Risk
NSAIDs, including celecoxib, cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events
(5.4)
.Carefully consider the potential benefits and risks of celecoxib and other treatment options before deciding to use celecoxib. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals [
see Warnings and Precautions (5)
]Use lowest effective dose for the shortest duration consistent with treatment goals for the individual patient. These doses can be given without regard to timing of meals.
Capsules: 50 mg, 100 mg, 200 mg and 400 mg
- Pregnancy Category C prior to 30 weeks gestation; Category D starting at 30 weeks gestation (5.9, 8.1, 17.8)
Celecoxib is contraindicated:
- In patients with known hypersensitivity to celecoxib, aspirin, or other NSAIDs.
- In patients who have demonstrated allergic-type reactions to sulfonamides.
- In patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe anaphylactoid reactions to NSAIDs, some of them fatal, have been reported in such patients [see Warnings and Precautions (5.7,5.13)].
- For the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG)surgery [see Warnings and Precautions(5.1)].
We receive information directly from the FDA and PrescriberPoint is updated as frequently as changes are made available