Tumor Necrosis Factor Receptor Blocking Activity

Tumor Necrosis Factor Blocker

Arthritis, Rheumatoid

Crohn Disease

Spondylitis, Ankylosing

Arthritis, Psoriatic

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-9"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">Certolizumab pegol  is a TNF blocker. CIMZIA is a recombinant, humanized antibody Fab' fragment, with specificity for human tumor necrosis factor alpha (TNFα), conjugated to an approximately 40kDa polyethylene glycol (PEG2MAL40K). The Fab' fragment is manufactured in           <span class="Italics">E. coli</span> and is subsequently subjected to purification and conjugation to PEG2MAL40K, to generate certolizumab pegol. The Fab' fragment is composed of a light chain with 214 amino acids and a heavy chain with 229 amino acids. The molecular weight of certolizumab pegol is approximately 91 kiloDaltons.       </p><p>CIMZIA (certolizumab pegol) for injection is supplied as a sterile white, lyophilized powder in a single-dose vial for subcutaneous use. After reconstitution of the lyophilized powder with 1 mL Sterile Water for Injection, USP, the final concentration is 200 mg/mL with a deliverable volume of 1 mL (200 mg) and a pH of approximately 5.2. Each single-dose vial provides 200 mg certolizumab pegol, lactic acid (0.9 mg), polysorbate (0.1 mg), and sucrose (100 mg).</p><p>CIMZIA (certolizumab pegol) injection is supplied as a sterile, clear to opalescent, colorless to pale yellow solution that may contain particulates in a single-dose prefilled syringe for subcutaneous use.  Each prefilled syringe delivers 1 mL of solution containing 200 mg certolizumab pegol, sodium acetate (1.36 mg), sodium chloride (7.31 mg), and Water for Injection, USP.</p></section>

Cimzia

certolizumab pegol

certolizumab pegol 200 MG Injection

certolizumab pegol 200 MG Injection [Cimzia]

1 ML certolizumab pegol 200 MG/ML Prefilled Syringe

1 ML certolizumab pegol 200 MG/ML Prefilled Syringe [Cimzia]

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Report Adverse Event 

Prescribing Information

Medication Guide

Submit MSL Request 

Reimbursement Information

Cimzia In-Office Injection Medical Benefit Flashcard

Coverage Authorization Request

Coverage Authorization Appeals

Letter of Medical Necessity 

Enroll in Patient Savings Program 

UCB Cares Foundation

CIMplicity Enrollment & Benefits Verification Form: Rheumatology & GI

CIMplicity Enrollment & Benefits Verification Form: Dermatology

CIMplicity HCP Office Portal

CIMplicity Support Program 

Receiving Cimzia (In Office Injections)

Taking Cimzia (At Home Injections)

About Cimzia: Plaque Psoriasis 

Side Effects: Plaque Psoriasis 

Doctor Discussion Guide: Plaque Psoriasis

About Cimzia: Psoriatic Arthritis

Side Effects: Psoriatic Arthritis 

Doctor Discussion Guide: Psoriatic Arthritis, Rheumatoid Arthritis 

About Cimzia: Rheumatoid Arthritis 

Patient Stories: Rheumatoid Arthritis 

Side Effects: Rheumatoid Arthritis 

About Cimzia: Ankylosing Spondylitis

Side Effects: Ankylosing Spondylitis 

Doctor Discussion Guide: Ankylosing Spondylitis 

About Cimzia: nr-axSpA

Patient Stories: nr-axSpA

Side Effects: nr-axSpA

Doctor Discussion Guide: nr-axSpA

About Cimzia: Crohn's Disease 

Side Effects: Crohn's Disease 

Doctor Discussion Guide: Crohn's Disease 

Instructions For Use: Plaque Psoriasis 

Instructions For Use: Psoriatic Arthritis

Instructions For Use: Rheumatoid Arthritis 

Instructions For Use: Ankylosing Spondylitis

Instructions For Use: nr-axSpA

Instructions For Use: Crohn's Disease 

Pharmacy List 