Nucleoside Reverse Transcriptase Inhibitors

Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor

HIV Infections

Hepatitis B, Chronic

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-10"></a><h1>11 DESCRIPTION</h1>DESCOVY (emtricitabine and tenofovir alafenamide) is a fixed dose combination tablet containing emtricitabine (FTC) and tenofovir alafenamide (TAF) for oral administration. <ul class="Disc"><li>FTC, a synthetic nucleoside analog of cytidine, is an HIV nucleoside analog reverse transcriptase inhibitor (HIV NRTI).</li><li>TAF, an HIV NRTI, is converted in vivo to tenofovir, an acyclic nucleoside phosphonate (nucleotide) analog of adenosine 5′-monophosphate.</li></ul>DESCOVY tablets are available in two dose strengths:<ul class="Disc"><li>200 mg/25 mg tablets: 200 mg of FTC and 25 mg of TAF (equivalent to 28 mg of tenofovir alafenamide fumarate).</li><li>120 mg/15 mg tablets: 120 mg of FTC and 15 mg of TAF (equivalent to 16.8 mg of tenofovir alafenamide fumarate).</li></ul>Both dose strengths of DESCOVY tablets include the following inactive ingredients: croscarmellose sodium, magnesium stearate, and microcrystalline cellulose. The 200 mg/ 25 mg tablets are film-coated with a coating material containing indigo carmine aluminum lake, polyethylene glycol, polyvinyl alcohol, talc, and titanium dioxide. The 120 mg/15 mg tablets are film-coated with a coating material containing polyvinyl alcohol, titanium dioxide, polyethylene glycol, and talc.<div class="Section" data-sectioncode="42229-5"><a name="section-10.1"></a>Emtricitabine: The chemical name of FTC is 4-amino-5-fluoro-1-(2R-hydroxymethyl-1,3-oxathiolan-5S-yl)-(1H)-pyrimidin-2-one. FTC is the (-)enantiomer of a thio analog of cytidine, which differs from other cytidine analogs in that it has a fluorine in the 5 position.FTC has a molecular formula of C8H10FN3O3S and a molecular weight of 247.24 and has the following structural formula:<img alt="Chemical Structure" src="descovy-01.jpg"/>FTC is a white to off-white powder with a solubility of approximately 112 mg per mL in water at 25 °C.</div><div class="Section" data-sectioncode="42229-5"><a name="section-10.2"></a>Tenofovir Alafenamide: The chemical name of tenofovir alafenamide fumarate drug substance is L-alanine, N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester, (2E)-2-butenedioate (2:1).Tenofovir alafenamide fumarate has an empirical formula of C21H29O5N6P∙½(C4H4O4) and a formula weight of 534.50 and has the following structural formula:<img alt="Chemical Structure" src="descovy-02.jpg"/>Tenofovir alafenamide fumarate is a white to off-white or tan powder with a solubility of 4.7 mg per mL in water at 20 °C.</div></section>

DESCOVY

tenofovir alafenamide

emtricitabine / tenofovir alafenamide

emtricitabine 200 MG / tenofovir alafenamide 25 MG Oral Tablet

Descovy

emtricitabine 200 MG / tenofovir alafenamide 25 MG Oral Tablet [Descovy]

emtricitabine 120 MG / tenofovir alafenamide 15 MG Oral Tablet

emtricitabine 120 MG / tenofovir alafenamide 15 MG Oral Tablet [Descovy]

emtricitabine

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Report Adverse Event

Prescribing Information

Medication Guide 

Submit MSL Request 

Pharmacy List 

Prior Authorization Checklist 

Coverage Authorization Request 

Coverage Authorization Appeals 

Letter of Medical Necessity 

Gilead Advancing Access Enrollment Form 

Enroll in Patient Savings Program 

Activate Co-Pay Card (if already have one)

Replace Co-Pay Card (if lost one)

Patient Assistance Program

Other HCP Resources

Billing & Coding Guide 

Patient Brochure 

About Descovy For PrEP

Taking Descovy For PrEP

Side Effects 

Patient Stories 

Patient Resources

Instructions For Use: HIV Pre-Exposure Prophylaxis

Instructions For Use: HIV

About Descovy: HIV