Diphenhydramine Drug Interactions: 46 Major, 827 Moderate
Diphenhydramine (Diphenhydramine Hydrochloride) Drug Interactions
Check all documented drug-to-drug interactions. Major, moderate, and minor interactions with descriptions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Diphenhydramine. Always confirm against the full prescribing information.
100 interactions
Abatacept
The metabolism of Diphenhydramine can be increased when combined with Abatacept.
Level 1 evidence
Abemaciclib
The risk or severity of methemoglobinemia can be increased when Abemaciclib is combined with Diphenhydramine.
Level 1 evidence
Abiraterone
The metabolism of Diphenhydramine can be decreased when combined with Abiraterone.
Level 1 evidence
Acebutolol
The metabolism of Acebutolol can be decreased when combined with Diphenhydramine.
Level 2 evidence
Acetazolamide
The risk or severity of methemoglobinemia can be increased when Acetazolamide is combined with Diphenhydramine.
Level 1 evidence
Acetic acid
The risk or severity of methemoglobinemia can be increased when Acetic acid is combined with Diphenhydramine.
Level 1 evidence
Acetyl sulfisoxazole
The risk or severity of methemoglobinemia can be increased when Acetyl sulfisoxazole is combined with Diphenhydramine.
Level 1 evidence
Acoramidis
The metabolism of Diphenhydramine can be decreased when combined with Acoramidis.
Level 2 evidence
Adagrasib
The risk or severity of methemoglobinemia can be increased when Adagrasib is combined with Diphenhydramine.
Level 1 evidence
Adalimumab
The metabolism of Diphenhydramine can be increased when combined with Adalimumab.
Level 1 evidence
Afatinib
The risk or severity of methemoglobinemia can be increased when Afatinib is combined with Diphenhydramine.
Level 1 evidence
Aldesleukin
The risk or severity of methemoglobinemia can be increased when Aldesleukin is combined with Diphenhydramine.
Level 1 evidence
Enter your NPI to unlock 3 major interactions for Diphenhydramine
Diphenhydramine (Diphenhydramine Hydrochloride) has 1080 documented drug interactions. Always review the full list with a pharmacist before co-prescribing.
Diphenhydramine (Diphenhydramine Hydrochloride) has 46 major, 827 moderate, and 207 minor documented interactions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Diphenhydramine. Always confirm against the full prescribing information.