Interleukin 4 Receptor alpha Antagonists

Interleukin-4 Receptor alpha Antagonist

Dermatitis, Atopic

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-9"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">Dupilumab, an interleukin-4 receptor alpha antagonist, is a human monoclonal antibody of the IgG4 subclass that binds to the IL-4Rα subunit and inhibits IL-4 and IL-13 signaling. Dupilumab has an approximate molecular weight of 147 kDa.</p><p>Dupilumab is produced by recombinant DNA technology in Chinese Hamster Ovary cell suspension culture.</p><p>DUPIXENT (dupilumab) Injection is supplied as a sterile, preservative-free, clear to slightly opalescent, colorless to pale yellow solution for subcutaneous injection. DUPIXENT is provided as either a single-dose pre-filled syringe with needle shield or a single-dose pre-filled pen in a siliconized Type-1 clear glass syringe. The needle cap is not made with natural rubber latex.</p><p>Each 300 mg pre-filled syringe or pre-filled pen delivers 300 mg dupilumab in 2 mL which also contains L-arginine hydrochloride (10.5 mg), L-histidine (6.2 mg), polysorbate 80 (4 mg), sodium acetate (2 mg), sucrose (100 mg), and water for injection, pH 5.9.</p><p>Each 200 mg pre-filled syringe or pre-filled pen delivers 200 mg dupilumab in 1.14 mL which also contains L-arginine hydrochloride (12 mg), L-histidine (3.5 mg), polysorbate 80 (2.3 mg), sodium acetate (1.2 mg), sucrose (57 mg), and water for injection, pH 5.9.</p></section>

Dupixent

dupilumab

2 ML dupilumab 150 MG/ML Prefilled Syringe

2 ML dupilumab 150 MG/ML Prefilled Syringe [Dupixent]

1.14 ML dupilumab 175 MG/ML Prefilled Syringe

1.14 ML dupilumab 175 MG/ML Prefilled Syringe [Dupixent]

2 ML dupilumab 150 MG/ML Auto-Injector

2 ML dupilumab 150 MG/ML Auto-Injector [Dupixent]

1.14 ML dupilumab 175 MG/ML Auto-Injector

1.14 ML dupilumab 175 MG/ML Auto-Injector [Dupixent]

0.67 ML dupilumab 150 MG/ML Prefilled Syringe

0.67 ML dupilumab 150 MG/ML Prefilled Syringe [Dupixent]

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Dupixent is an injectable medication that is typically administered subcutaneously every other week to treat inflammatory conditions, such as asthma and eczema, among others. Injection site reactions and eye conditions are the most frequently reported side effects. The risk of infection is low with Dupixent, unlike other biologics. 

Dupixent is FDA approved for the following indications: Atopic Dermatitis, Asthma, Chronic Rhinosinusitis with Nasal Polyposis, Eosinophilic Esophagitis, Prurigo Nodularis. 


Report Adverse Event 

Prescribing Information 

Prescribing Information - Spanish 

Medication Guide 

Medication Guide - Spanish

Submit MSL Request 

Pharmacy List 

Formulary Coverage 

Billing & Coding Guide 

Dupixent MyWay Enrollment Forms - All Indications

Enroll in Patient Savings Program 

Bridge Program 

Dupixent Patient Assitance Program Eligibility (Through Dupixent MyWay Program )

Coverage Authorization Request 

Coverage Authorization Appeal 

Medical Exception Letter 

Other HCP Resources: Atopic Dermatitis

Prior Authorization & Appeals Guide: Atopic Dermatitis 

PA Checklist: Atopic Dermatitis 

About Dupixent: Atopic Dermatitis 

Patient Stories: Atopic Dermatitis 

FAQs: Atopic Dermatitis 

Instructions For Use: Atopic Dermatitis 

Doctor Discussion Guide: Atopic Dermatitis

Taking Dupixent: Atopic Dermatitis

Other HCP Resources: Asthma

Prior Authorization & Appeals Guide: Asthma 

PA Checklist: Asthma 

About Dupixent: Asthma 

FAQs: Asthma 

Patient Stories: Asthma 

Instructions For Use: Asthma 

Doctor Discussion Guide: Asthma

Taking Dupixent: Asthma 

Prior Authorization & Appeals Guide: Eosinophilic Esophagitis 

PA Checklist: Eosinophilic Esophagitis 

About Dupixent: Eosinophilic Esophagitis 

Instructions For Use: Eosinophilic Esophagitis 

Taking Dupixent: Eosinophilic Esophagitis 

FAQs: Eosinophilic Esophagitis 

Prior Authorization & Appeals Guide: Prurigo Nodularis

PA Checklist: Prurigo Nodularis

About Dupixent: Prurigo Nodularis

Taking Dupixent: Prurigo Nodularis

FAQs: Prurigo Nodularis

Instructions For Use: Prurigo Nodularis

Other HCP Resources: Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP)

Prior Authorization & Appeals Guide: Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP)

PA Checklist: Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP)

About Dupixent: Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP)

Patient Stories: Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP)

FAQs: Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP) 

Instructions For Use: Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP)

Doctor Discussion Guide: Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP)

Taking Dupixent: Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP)

Comprehensive Support Program 

Nursing Support

Instructions For Use: Pre-filled Syringe 100mg 

Instructions For Use: Pre-filled Syringe 100mg (Spanish)

Instructions For Use: Pre-filled Syringe 200mg 

Instructions For Use: Pre-filled Syringe 200mg (Spanish)

Instructions For Use: Pre-filled Syringe 300mg 

Instructions For Use: Pre-filled Syringe 300mg (Spanish)

Instructions For Use: Pre-filled Pen 200 mg 

Instructions For Use: Pre-filled Pen 200 mg (Spanish)

Instructions For Use: Pre-filled Pen 300 mg 

Instructions For Use: Pre-filled Pen 300 mg (Spanish)