Integrin Receptor Antagonists

Integrin Receptor Antagonist

Colitis, Ulcerative

Crohn Disease

Enteritis

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-9"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">Vedolizumab, an integrin receptor antagonist, is a humanized IgG<span class="Sub">1 </span>monoclonal antibody produced in Chinese hamster ovary cells that binds to the human α4β7 integrin. ENTYVIO has an approximate molecular weight of 147 kilodaltons.</p><div class="Section" data-sectioncode="42229-5"><a name="section-9.1"></a><p></p><p class="First"><span class="Italics Underline">Intravenous ENTYVIO</span></p><p>ENTYVIO (vedolizumab) for injection is supplied as a sterile, white to off-white, preservative-free, lyophilized cake for intravenous infusion. After reconstitution with 4.8 mL Sterile Water for Injection, USP, 0.9% Sodium Chloride Injection, USP, or Lactated Ringer's Injection, USP, the resulting concentration is 60 mg/mL with a deliverable volume of 5 mL (300 mg) and the resulting pH is approximately 6.3.</p><p>Each single-dose vial contains 300 mg vedolizumab, arginine hydrochloride (131.7 mg), histidine (23 mg), histidine monohydrochloride (21.4 mg), polysorbate 80 (3 mg), and sucrose (500 mg).</p></div><div class="Section" data-sectioncode="42229-5"><a name="section-9.2"></a><p></p><p class="First"><span class="Italics Underline">Subcutaneous ENTYVIO</span></p><p>ENTYVIO (vedolizumab) injection is supplied as a sterile, clear to moderately opalescent, colorless to slightly yellow, preservative-free solution for subcutaneous administration.</p><p>Each single-dose prefilled syringe or single-dose prefilled pen (ENTYVIO PEN) contains 108 mg vedolizumab, arginine hydrochloride (17.77 mg), citric acid monohydrate (0.18 mg), histidine (3.86 mg), histidine monohydrochloride (1.86 mg), polysorbate 80 (1.35 mg), sodium citrate dihydrate (4.71 mg) and Sterile Water for Injection, USP, at a pH of 6.5.</p></div></section>

Entyvio

vedolizumab

vedolizumab 300 MG Injection

vedolizumab 300 MG Injection [Entyvio]

0.68 ML vedolizumab 159 MG/ML Prefilled Syringe

0.68 ML vedolizumab 159 MG/ML Prefilled Syringe [Entyvio]

0.68 ML vedolizumab 159 MG/ML Auto-Injector

0.68 ML vedolizumab 159 MG/ML Auto-Injector [Entyvio]

HOAB Pharmacy

HOAA Pharmacy

HMH Specialty Pharmacy

Hill Country Pharmacy

Keystone Specialty Pharmacy

Chemique Pharmaceuticals

Birmingham Vital Care

Axium Healthcare de Puerto Rico

Apotheco Pharmacy Group

Alps Specialty Pharmacy

Versiti Blood Center of Wisconsin Pharmacy

University Hospital Specialty Pharmacy

Sanford Pharmacy Broadway

Rochester Health Mart Pharmacy

Quality Home Infusion

CareMed Specialty Pharmacy

Price Rite Pharmacy

P3 Compounding Pharmacy

One Pharmacy

Novant Health Pharmacy Services

Specialty Pharmacies for Entyvio