Dermatitis, Atopic

Graft vs Host Disease

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-10"></a><h1>11 DESCRIPTION</h1>Tacrolimus is the active ingredient in ENVARSUS XR. Tacrolimus is a calcineurin-inhibitor immunosuppressant produced by Streptomyces tsukubaensis. Chemically, tacrolimus is designated as [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclo-hexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, monohydrate.The chemical structure of tacrolimus is:<img alt="chemical-structure" src="envarsusxr-figure-1.jpg"/>Tacrolimus has an empirical formula of C44H69NO12•H2O and a formula weight of 822.03. Tacrolimus appears as white crystals or crystalline powder. It is practically insoluble in water, freely soluble in ethanol, and very soluble in methanoland chloroform.ENVARSUS XR is available for oral administration as extended-release tablets containing the equivalent of 0.75 mg,1 mg, or 4 mg of anhydrous tacrolimus USP. Inactive ingredients include hypromellose USP, lactose monohydrate NF,polyethylene glycol NF, poloxamer NF, magnesium stearate NF, tartaric acid NF, butylated hydroxytoluene NF, anddimethicone NF.</section>

Envarsus

24 HR tacrolimus 4 MG Extended Release Oral Tablet

24 HR tacrolimus 4 MG Extended Release Oral Tablet [Envarsus]

24 HR tacrolimus 0.75 MG Extended Release Oral Tablet

24 HR tacrolimus 0.75 MG Extended Release Oral Tablet [Envarsus]

24 HR tacrolimus 1 MG Extended Release Oral Tablet

24 HR tacrolimus 1 MG Extended Release Oral Tablet [Envarsus]

tacrolimus

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