Epinephrine

Injection solution: 1 mL single-dose clear glass vial containing 1 mg/mL epinephrine as a sterile, nonpyrogenic, clear and colorless solution.

Injection solution: 10 mL multiple dose amber glass vial containing 10 mg/10 mL (1 mg/mL) epinephrine as a sterile, nonpyrogenic, clear and colorless solution. 

Injection solution: 30 mL multiple dose amber glass vial containing 30 mg/30 mL (1 mg/mL) epinephrine as a sterile, nonpyrogenic, clear and colorless solution.

• α-blockers, such as phentolamine
• Vasodilators, such as nitrates
• Diuretics
• Antihypertensives
• Ergot alkaloids

• Sympathomimetics
• β-blockers, such as propranolol
• Tricyclic anti-depressants
• Monoamine oxidase (MAO) inhibitors
• Catechol-O-methyl transferase (COMT) inhibitors, such as entacapone
• Clonidine
• Doxapram
• Oxytocin

• β-blockers, such as propranolol
• Cyclopropane or halogenated hydrocarbon anesthetics, such as halothane
• Antihistamines
• Thyroid hormones
• Diuretics
• Cardiac glycosides, such as digitalis glycosides
• Quinidine

• Potassium depleting diuretics
• Corticosteroids
• Theophylline

Epinephrine should not be used to counteract circulatory collapse or hypotension caused by phenothiazines, as a reversal of the pressor effects of epinephrine may result in further lowering of blood pressure.

Epinephrine may antagonize the neuronal blockade produced by guanethidine resulting in decreased antihypertensive effect and requiring increased dosage of the latter. 

Epinephrine Injection, USP is a clear, colorless, sterile solution containing 1 mg/mL epinephrine.

1 mL single-dose clear glass vial containing 1 mg/mL epinephrine as a sterile, nonpyrogenic, clear and colorless solution. Each mL of Epinephrine Injection, USP solution contains 1 mg epinephrine, 8.6 mg Sodium chloride, 0.75 mg sodium metabisulfite, q.s hydrochloric acid as a dissolution and  pH adjustment, and water for injection. The pH range is 2.2-5.0.

Epinephrine is a sympathomimetic catecholamine. The chemical name of epinephrine is: 1,2- Benzenediol, 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]-, or (-)-3,4-Dihydroxy-α-[2- (methylamino)ethyl]benzyl alcohol. The chemical structure of epinephrine is:

The molecular weight of epinephrine is 183.2.

Epinephrine solution deteriorates rapidly on exposure to air or light, turning pink from oxidation to adrenochrome and brown from the formation of melanin.

Epinephrine Injection supplied as a clear colorless solution available as follows:

Each carton contains 10 single-dose vials containing 1 mL of a 1 mg/mL epinephrine injection, USP solution in a clear glass vial.

NDC 54288-119-10                  Box of 10 × 1 mL Single-Dose Vials

Each carton contains 25 single-dose vials containing 1 mL of a 1 mg/mL epinephrine injection, USP solution in a clear glass vial.

NDC 54288-119-25                 Box of 25 × 1 mL Single-Dose Vials

Each carton contains 1 multiple dose vial containing 10 mg/10 mL (1 mg/mL) epinephrine injection, USP solution in an amber glass vial.

NDC 54288-120-01               10 mL Multiple Dose Vial

Multiple Dose Vial and contents must be discarded 30 days after initial use.

NDC 54288-152-01               30 mL Multiple Dose Vial

Multiple Dose Vial and contents must be discarded 30 days after initial use.

Epinephrine is light sensitive. Protect from light until ready to use.

Do not refrigerate. Protect from freezing.

Store at room temperature, between 20°C to 25°C (68°F to 77°F). (See USP Controlled Room Temperature.) Protect from alkalis and oxidizing agents.