Isoproterenol Hydrochloride
Isoproterenol Hydrochloride Prescribing Information
Isoproterenol hydrochloride injection is indicated:
- To improve hemodynamic status in patients in distributive shock and shock due to reduced cardiac output
- For bronchospasm occurring during anesthesia
Injection solution: single dose, clear glass vials containing isoproterenol in a clear, colorless solution;
- 1 mL containing 0.2 mg/1 mL (0.2 mg/mL)
- 5 mL containing 1 mg/5 mL (0.2 mg/mL)
Isoproterenol hydrochloride injection is contraindicated in patients with:
- tachycardia
- ventricular arrhythmias
- angina pectoris
The following adverse reactions have been associated with use of isoproterenol. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency reliably or to establish a causal relationship to drug exposure.
Epinephrine | |
| Clinical Impact | Both drugs are direct cardiac stimulants, and their combined effects may induce serious arrhythmias upon simultaneous administration. |
| Intervention | Isoproterenol hydrochloride injection and epinephrine should not be administered simultaneously. |
Drugs that may potentiate clinical response of Isoproterenol | |
| Clinical Impact | The effects of isoproterenol may be potentiated by tricyclic antidepressants, monoamine oxidase inhibitors, levothyroxinesodium, and certain antihistamines, notably chlorpheniramine, tripelennamine, and diphenhydramine. |
| Intervention | Monitor hemodynamic parameters in patients who concurrently are taking tricyclic antidepressants, monoamine oxidase inhibitors, levothyroxine sodium and certain antihistamines. Adjust doses appropriately. |
Drugs that may reduce clinical response of Isoproterenol | |
| Clinical Impact | The cardiostimulating and bronchodilating effects of isoproterenol are antagonized by beta-adrenergic blocking drugs, such as propranolol. |
| Intervention | Monitor for hemodynamic response and relief of bronchospasm and adjust dose appropriately. |
Isoproterenol hydrochloride, USP is 3,4-Dihydroxy-α-[(isopropylamino)methyl] benzyl alcohol hydrochloride, a synthetic sympathomimetic amine that is structurally related to epinephrine but acts almost exclusively on beta receptors. The molecular formula is C11H17NO3 • HCl. It has a molecular weight of 247.72 and the following structural formula:
Isoproterenol hydrochloride, USP is a racemic compound.
 |
| Each milliliter of the sterile solution contains: | |
| Isoproterenol Hydrochloride, USP | 0.2 mg |
| Edetate Disodium (EDTA) | 0.2 mg |
| Sodium Chloride | 7.0 mg |
| Sodium Citrate, Dihydrate | 2.07 mg |
| Citric Acid, Anhydrous | 2.5 mg |
| Water for Injection | 1.0 mL |
The pH is adjusted between 2.5 and 4.5 with hydrochloric acid or sodium hydroxide.
The sterile solution is nonpyrogenic and can be administered by the intravenous, intramuscular, subcutaneous, or intracardiac routes.