Klor-con

Klor-Con is indicated for the treatment and prophylaxis of hypokalemia with or without metabolic alkalosis, in patients for whom dietary management with potassium-rich foods or diuretic dose reduction is insufficient.

• Monitor serum potassium and adjust dosages accordingly. (
  
  
  2.1 Administration and Monitoring

  If serum potassium concentration is less than 2.5 mEq/L, use intravenous potassium instead of oral supplementation.

  Monitoring

  Monitor serum potassium and adjust dosages accordingly. Monitor serum potassium periodically during maintenance therapy to ensure potassium remains in desired range.

  The treatment of potassium depletion, particularly in the presence of cardiac disease, renal disease, or acidosis, requires careful attention to acid-base balance, volume status, electrolytes, including magnesium, sodium, chloride, phosphate, and calcium, electrocardiograms, and the clinical status of the patient. Correct volume status, acid-base balance, and electrolyte deficits as appropriate.

  Administration

  Take Klor-Con with meals and with a glass of water or other liquid. Do not take Klor-Con on an empty stomach because of its potential for gastric irritation

  [see Warnings and Precautions (5.1)]

  .

  Swallow tablets whole without crushing, chewing or sucking.
  )
  
• If serum potassium is less than 2.5 mEq/L, use intravenous potassium instead of oral supplementation. (
  
  
  2.1 Administration and Monitoring

  If serum potassium concentration is less than 2.5 mEq/L, use intravenous potassium instead of oral supplementation.

  Monitoring

  Monitor serum potassium and adjust dosages accordingly. Monitor serum potassium periodically during maintenance therapy to ensure potassium remains in desired range.

  The treatment of potassium depletion, particularly in the presence of cardiac disease, renal disease, or acidosis, requires careful attention to acid-base balance, volume status, electrolytes, including magnesium, sodium, chloride, phosphate, and calcium, electrocardiograms, and the clinical status of the patient. Correct volume status, acid-base balance, and electrolyte deficits as appropriate.

  Administration

  Take Klor-Con with meals and with a glass of water or other liquid. Do not take Klor-Con on an empty stomach because of its potential for gastric irritation

  [see Warnings and Precautions (5.1)]

  .

  Swallow tablets whole without crushing, chewing or sucking.
  )
  
• Take with meals and with a glass of water or other liquid. Swallow tablets whole without crushing, chewing or sucking. (
  
  
  2.1 Administration and Monitoring

  If serum potassium concentration is less than 2.5 mEq/L, use intravenous potassium instead of oral supplementation.

  Monitoring

  Monitor serum potassium and adjust dosages accordingly. Monitor serum potassium periodically during maintenance therapy to ensure potassium remains in desired range.

  The treatment of potassium depletion, particularly in the presence of cardiac disease, renal disease, or acidosis, requires careful attention to acid-base balance, volume status, electrolytes, including magnesium, sodium, chloride, phosphate, and calcium, electrocardiograms, and the clinical status of the patient. Correct volume status, acid-base balance, and electrolyte deficits as appropriate.

  Administration

  Take Klor-Con with meals and with a glass of water or other liquid. Do not take Klor-Con on an empty stomach because of its potential for gastric irritation

  [see Warnings and Precautions (5.1)]

  .

  Swallow tablets whole without crushing, chewing or sucking.
  )
  
• Treatment of hypokalemia:
  Doses range from 40 to 100 mEq/day in divided doses. Limit doses to 40 mEq per dose. (
  
  
  2.2 Dosing

  Dosage must be adjusted to the individual needs of each patient. Dosages greater than 40 mEq per day should be divided such that no more than 40 mEq is given in a single dose.

  Treatment of Hypokalemia:

  Typical dose range is 40 to 100 mEq per day.

  Maintenance or Prophylaxis:

  Typical dose range is 20 mEq per day.
  )
  
• Prevention of hypokalemia:
  Typical dose is 20 mEq per day. (
  
  
  2.2 Dosing

  Dosage must be adjusted to the individual needs of each patient. Dosages greater than 40 mEq per day should be divided such that no more than 40 mEq is given in a single dose.

  Treatment of Hypokalemia:

  Typical dose range is 40 to 100 mEq per day.

  Maintenance or Prophylaxis:

  Typical dose range is 20 mEq per day.
  )
  

Klor-Con extended-release tablets are supplied as:

600 mg (8 mEq) are film-coated, round light blue tablets debossed with "KC 8".

750 mg (10 mEq) are film-coated, round yellow tablets debossed with "KC 10".

• Cirrhosis: Initiate therapy at the low end of the dosing range (
  
  
  8.6 Cirrhotics

  Based on published literature, the baseline corrected serum concentrations of potassium measured over 3 hours after administration in cirrhotic subjects who received an oral potassium load rose to approximately twice that of normal subjects who received the same load. Patients with cirrhosis should usually be started at the low end of the dosing range, and the serum potassium level should be monitored frequently

  [see Clinical Pharmacology (12.3)]

  .
  )
  
• Renal Impairment: Initiate therapy at the low end of the dosing range (
  
  
  8.7 Renal Impairment

  Patients with renal impairment have reduced urinary excretion of potassium and are at substantially increased risk of hyperkalemia. Patients with impaired renal function, particularly if the patient is on RAAS inhibitors or NSAIDs, should usually be started at the low end of the dosing range because of the potential for development of hyperkalemia

  [see Drug Interactions (7.2, 7.3)]

  . The serum potassium level should be monitored frequently. Renal function should be assessed periodically.
  )
  

• Gastrointestinal Irritation: Take with meals. (
  
  
  5.1 Gastrointestinal Adverse Reactions

  Solid oral dosage forms of potassium chloride can produce ulcerative and/or stenotic lesions of the gastrointestinal tract, particularly if the drug maintains contact with the gastrointestinal mucosa for prolonged periods. Consider the use of liquid potassium in patients with dysphagia, swallowing disorders, or severe gastrointestinal motility disorders.

  If severe vomiting, abdominal pain, distention, or gastrointestinal bleeding occurs, discontinue Klor-Con extended-release tablets and consider possibility of ulceration, obstruction or perforation.

  Klor-Con extended-release tablets should not be taken on an empty stomach because of its potential for gastric irritation

  [see Dosage and Administration (2.1)]

  .
  )