Krystexxa

(pegloticase)

Krystexxa 8 MG in 1 ML Injection

Dosage & administration

* Recommended Dosage: The recommended dosage is KRYSTEXXA 8 mg every two weeks given as an intravenous infusion, co-administered with weekly methotrexate 15 mg orally. KRYSTEXXA alone may be used in patients for whom methotrexate is contraindicated or not clinically appropriate.
* Methotrexate with folic acid or folinic acid supplementation should be initiated at least 4 weeks prior to initiating, and throughout treatment with KRYSTEXXA.
* Discontinue oral urate-lowering agents before starting KRYSTEXXA.
* Monitor serum uric acid levels before each infusion.
* Pre-medicate patients with antihistamines and corticosteroids.
* KRYSTEXXA must be diluted prior to use.
* Do not administer as an intravenous push or bolus. The KRYSTEXXA admixture should only be administered by intravenous infusion over no less than 120 minutes via gravity feed, syringe-type pump, or infusion pump.

drug label

Krystexxa prescribing information

Contact Medical Science Liaison Report Adverse Event

prior authorization

Krystexxa prior authorization resources

Most recent Krystexxa prior authorization forms

View By Payer

Verified: Oct 02, 2023Blue Cross Blue Shield of Michigan - FEP Krystexxa Prior Authorization Form (Medical Benefit)

Verified: Sep 28, 2023Cigna - Krystexxa Prior Authorization Form

Verified: Sep 26, 2023Blue Cross Blue Shield of Michigan - Krystexxa Prior Authorization Form (Medical Benefit)

OTHERComplete Letter of Medical Necessity

OTHERPA Guide

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Benefits investigation

PDFKrystexxa Patient Enrollment Form

Krystexxa Patient Enrollment Form - Online

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pharmacy

Krystexxa preferred pharmacy

PDFPharmacy List

financial assistance

Krystexxa financial assistance options

Co-pay savings program

commercial only

PDFKrystexxa Patient Enrollment Form

Krystexxa Patient Enrollment Form - Online

OTHEREnroll in Patient Savings Program

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Overview

Reduce patient OOP costs for drug (and occasionally for drug administration/infusion costs or drug-related test costs)

Patient benefit

A portion (or all) of patient OOP (deductible, copay), typically up to monthly and/or annual max

Patient eligibility

Patient must enroll or activate (may permit HCPs to enroll on patient’s behalf for HCP-administered drugs)
Generally, must have commercial insurance (rarely, may permit uninsured patients to use)
May never be used with government insurance

How to sign up

Cards may be downloadable digital cards or hard copies
Some pharmacos offer debit cards with pre-loaded copay benefit
Typically, available through multiple channels (e.g., rep to HCP to patient; pharmacy to patient; patient via website, Hub live agent, or copay vendor (live agent or IVR); patient and HCP via Hub enrollment form)
Some HCP-administered product programs permit HCPs to enroll on a patient’s behalf through via Hub form

patient education

Krystexxa patient education

Getting started on Krystexxa

To share resource; ask patient to:

1.Pull out phone

2.Open camera

3.Scan QR code with camera

4.Tap link