Leflunomide Drug Interactions: 19 Major, 451 Moderate
Leflunomide Drug Interactions
Check all documented drug-to-drug interactions. Major, moderate, and minor interactions with descriptions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Leflunomide. Always confirm against the full prescribing information.
100 interactions
Abatacept
The risk or severity of adverse effects can be increased when Abatacept is combined with Leflunomide.
Level 2 evidence
Abrocitinib
The metabolism of Abrocitinib can be decreased when combined with Leflunomide.
Level 2 evidence
Acenocoumarol
The serum concentration of Acenocoumarol can be decreased when it is combined with Leflunomide.
Level 1 evidence
Acetaminophen
The serum concentration of Acetaminophen can be decreased when it is combined with Leflunomide.
Level 1 evidence
Acoramidis
The metabolism of Leflunomide can be decreased when combined with Acoramidis.
Level 2 evidence
Activated charcoal
Activated charcoal can cause a decrease in the absorption of Leflunomide resulting in a reduced serum concentration and potentially a decrease in efficacy.
Level 1 evidence
Acyclovir
The serum concentration of Acyclovir can be decreased when it is combined with Leflunomide.
Level 1 evidence
Adagrasib
The metabolism of Leflunomide can be decreased when combined with Adagrasib.
Level 2 evidence
Adalimumab
The risk or severity of adverse effects can be increased when Adalimumab is combined with Leflunomide.
Level 2 evidence
Aficamten
The metabolism of Aficamten can be decreased when combined with Leflunomide.
Level 2 evidence
Albendazole
The serum concentration of Albendazole can be decreased when it is combined with Leflunomide.
Level 1 evidence
Aldesleukin
The risk or severity of adverse effects can be increased when Aldesleukin is combined with Leflunomide.
Level 2 evidence
Enter your NPI to unlock 2 major interactions for Leflunomide
Leflunomide has 1084 documented drug interactions. Always review the full list with a pharmacist before co-prescribing.
Leflunomide has 19 major, 451 moderate, and 614 minor documented interactions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Leflunomide. Always confirm against the full prescribing information.