Lysosomal beta Glucuronidase

<section class="Section" data-sectioncode="34089-3"><a name="section-8"></a><p></p><h1><span class="Bold">11</span><span class="Bold">  </span><span class="Bold">DESCRIPTION </span></h1><p class="First">Vestronidase alfa-vjbk is a recombinant human lysosomal beta glucuronidase which is a purified human enzyme produced by recombinant DNA technology in a Chinese hamster ovary cell line. </p><p>Purified vestronidase alfa-vjbk exists as a homotetramer, with each monomer consisting of 629 amino acids. The calculated isotope average molecular mass of each non-glycosylated peptide chain is 72,562 Da. </p><p>The amino acid sequence for vestronidase alfa-vjbk is the same as the amino acid sequence for human beta-glucuronidase (GUS). </p><p>MEPSEVII (vestronidase alfa-vjbk) injection for intravenous infusion is a sterile, preservative-free, non-pyrogenic, colorless to slightly yellow liquid supplied in a single-dose vial. Each mL of solution contains vestronidase alfa-vjbk (2 mg), L-histidine (3.1 mg), polysorbate 20 (0.1 mg), sodium chloride (7.88 mg) and sodium phosphate monobasic dihydrate (3.12 mg). The pH of the solution is 6.0.</p></section>

MEPSEVII

vestronidase alfa-vjbk

vestronidase alfa

5 ML vestronidase alfa-vjbk 2 MG/ML Injection

Mepsevii

5 ML vestronidase alfa-vjbk 2 MG/ML Injection [Mepsevii]

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Instructions For Use: Mucopolysaccharidosis VII (MPS VII, Sly syndrome)