Methotrexate Drug Interactions: 402 Major, 715 Moderate
Methotrexate Drug Interactions
Check all documented drug-to-drug interactions. Major, moderate, and minor interactions with descriptions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Methotrexate. Always confirm against the full prescribing information.
100 interactions
5-methyltetrahydrofolic acid
The therapeutic efficacy of Methotrexate can be decreased when used in combination with 5-methyltetrahydrofolic acid.
Level 2 evidence
Abacavir
The risk or severity of liver damage can be increased when Methotrexate is combined with Abacavir.
Level 2 evidence
Abemaciclib
Abemaciclib may decrease the excretion rate of Methotrexate which could result in a higher serum level.
Level 2 evidence
Abiraterone
The risk or severity of liver damage can be increased when Methotrexate is combined with Abiraterone.
Level 2 evidence
Acamprosate
The risk or severity of liver damage can be increased when Methotrexate is combined with Acamprosate.
Level 2 evidence
Acarbose
The risk or severity of liver damage can be increased when Acarbose is combined with Methotrexate.
Level 2 evidence
Acebutolol
The risk or severity of liver damage can be increased when Methotrexate is combined with Acebutolol.
Level 2 evidence
Acetazolamide
The therapeutic efficacy of Methotrexate can be increased when used in combination with Acetazolamide.
Level 1 evidence
Acetohydroxamic acid
The risk or severity of liver damage can be increased when Acetohydroxamic acid is combined with Methotrexate.
Level 2 evidence
Acyclovir
The excretion of Acyclovir can be decreased when combined with Methotrexate.
Level 2 evidence
Adefovir dipivoxil
The risk or severity of nephrotoxicity can be increased when Methotrexate is combined with Adefovir dipivoxil.
Level 2 evidence
Afatinib
Afatinib may decrease the excretion rate of Methotrexate which could result in a higher serum level.
Level 2 evidence
Enter your NPI to unlock 25 major interactions for Methotrexate
Methotrexate has 1351 documented drug interactions. Always review the full list with a pharmacist before co-prescribing.
Methotrexate has 402 major, 715 moderate, and 234 minor documented interactions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Methotrexate. Always confirm against the full prescribing information.