Hypotension, Orthostatic

<section class="Section" data-sectioncode="34089-3"><a name="LINK_03b9cb1b-79ab-413e-8c60-aae67f6bebe6"></a><a name="section-10"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">NORTHERA capsules contain droxidopa, which is a synthetic amino acid precursor of norepinephrine, for oral administration. Chemically, droxidopa is (–)-threo-3-(3,4-Dihydroxyphenyl)-L-serine. It has the following structural formula:</p><div class="Figure"><img alt="northera-01" src="northera-1.jpg"/></div><p>Droxidopa is an odorless, tasteless, white to off-white crystals or crystalline powder. It is slightly soluble in water, and practically insoluble in methanol, glacial acetic acid, ethanol, acetone, ether, and chloroform. It is soluble in dilute hydrochloric acid. It has a molecular weight of 213.19 and a molecular formula of C<span class="Sub">9</span>H<span class="Sub">11</span>NO<span class="Sub">5</span>. </p><p>NORTHERA capsules also contain the following inactive ingredients: mannitol, corn starch, and magnesium stearate. The capsule shell is printed with black ink. The black inks contain shellac glaze, ethanol, iron oxide black, isopropyl alcohol, n-butyl alcohol, propylene glycol, and ammonium hydroxide. The capsule shell contains the following inactive ingredients: 100 mg –­ gelatin, titanium dioxide, FD&amp;C Blue No. 2, black and red iron oxide; 200 mg – gelatin, titanium dioxide, FD&amp;C Blue No. 2, black and yellow iron oxide; 300 mg – gelatin, titanium dioxide, FD&amp;C Blue No. 1, FD&amp;C Yellow No. 5 (tartrazine), and FD&amp;C Red No. 40. NORTHERA capsules differ in size and color by strength <span class="Italics">[see Dosage Forms and Strengths (<a href="#LINK_4979dc38-1686-4baf-ac2e-c20046f07bc0">3</a>)]</span>.</p></section>

Northera

droxidopa

droxidopa 100 MG Oral Capsule

droxidopa 100 MG Oral Capsule [Northera]

droxidopa 200 MG Oral Capsule

droxidopa 200 MG Oral Capsule [Northera]

droxidopa 300 MG Oral Capsule

droxidopa 300 MG Oral Capsule [Northera]

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