Pemetrexed Drug Interactions: 203 Major, 1000 Moderate
Pemetrexed (Pemetrexed Disodium) Drug Interactions
Check all documented drug-to-drug interactions. Major, moderate, and minor interactions with descriptions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Pemetrexed. Always confirm against the full prescribing information.
100 interactions
5-methyltetrahydrofolic acid
The therapeutic efficacy of Pemetrexed can be decreased when used in combination with 5-methyltetrahydrofolic acid.
Level 2 evidence
Abacavir
Abacavir may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Level 2 evidence
Abatacept
The metabolism of Pemetrexed can be increased when combined with Abatacept.
Level 1 evidence
Abemaciclib
The risk or severity of liver damage can be increased when Pemetrexed is combined with Abemaciclib.
Level 2 evidence
Acalabrutinib
The risk or severity of liver damage can be increased when Pemetrexed is combined with Acalabrutinib.
Level 2 evidence
Acamprosate
The risk or severity of liver damage can be increased when Pemetrexed is combined with Acamprosate.
Level 2 evidence
Acarbose
The risk or severity of liver damage can be increased when Acarbose is combined with Pemetrexed.
Level 2 evidence
Acebutolol
The risk or severity of liver damage can be increased when Pemetrexed is combined with Acebutolol.
Level 2 evidence
Aceclofenac
Aceclofenac may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Level 1 evidence
Acenocoumarol
The metabolism of Acenocoumarol can be decreased when combined with Pemetrexed.
Level 2 evidence
Acetaminophen
Acetaminophen may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Level 2 evidence
Acetazolamide
The therapeutic efficacy of Pemetrexed can be increased when used in combination with Acetazolamide.
Level 1 evidence
Enter your NPI to unlock 12 major interactions for Pemetrexed
Pemetrexed (Pemetrexed Disodium) has 1246 documented drug interactions. Always review the full list with a pharmacist before co-prescribing.
Pemetrexed (Pemetrexed Disodium) has 203 major, 1000 moderate, and 43 minor documented interactions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Pemetrexed. Always confirm against the full prescribing information.