Phenytoin Drug Interactions: 411 Major, 643 Moderate
Phenytoin Drug Interactions
Check all documented drug-to-drug interactions. Major, moderate, and minor interactions with descriptions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Phenytoin. Always confirm against the full prescribing information.
100 interactions
5-methyltetrahydrofolic acid
The serum concentration of Phenytoin can be decreased when it is combined with 5-methyltetrahydrofolic acid.
Level 1 evidence
Abacavir
The metabolism of Abacavir can be increased when combined with Phenytoin.
Level 2 evidence
Abiraterone
The metabolism of Abiraterone can be increased when combined with Phenytoin.
Level 1 evidence
Abrocitinib
The metabolism of Abrocitinib can be increased when combined with Phenytoin.
Level 2 evidence
Acarbose
The therapeutic efficacy of Acarbose can be decreased when used in combination with Phenytoin.
Level 2 evidence
Acebutolol
The metabolism of Phenytoin can be decreased when combined with Acebutolol.
Level 2 evidence
Acenocoumarol
The metabolism of Acenocoumarol can be increased when combined with Phenytoin.
Level 1 evidence
Acetaminophen
Phenytoin may increase the hepatotoxic activities of Acetaminophen.
Level 1 evidence
Acetazolamide
The risk or severity of osteomalacia can be increased when Acetazolamide is combined with Phenytoin.
Level 1 evidence
Acitretin
Phenytoin may increase the hepatotoxic activities of Acitretin.
Level 2 evidence
Adenine
The metabolism of Phenytoin can be decreased when combined with Adenine.
Level 2 evidence
Aficamten
The metabolism of Aficamten can be increased when combined with Phenytoin.
Level 1 evidence
Enter your NPI to unlock 37 major interactions for Phenytoin
Phenytoin has 1231 documented drug interactions. Always review the full list with a pharmacist before co-prescribing.
Phenytoin has 411 major, 643 moderate, and 177 minor documented interactions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Phenytoin. Always confirm against the full prescribing information.