Platelet-derived Growth Factor alpha Receptor Inhibitors

Stem Cell Factor (KIT) Receptor Inhibitors

Kinase Inhibitor

P-Glycoprotein Inhibitors

Cytochrome P450 2C8 Inhibitors

Breast Cancer Resistance Protein Inhibitors

Gastrointestinal Stromal Tumors

<section class="Section" data-sectioncode="34089-3"><a name="s41"></a><a name="section-9"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">Ripretinib is a kinase inhibitor. The chemical name of ripretinib is 1-(4-bromo-5-[1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl]-2-fluorophenyl)-3-phenylurea. The molecular formula is C<span class="Sub">24</span>H<span class="Sub">21</span>BrFN<span class="Sub">5</span>O<span class="Sub">2</span> and the molecular weight is 510.36 g/mol. The chemical structure of ripretinib is shown below:</p><div class="Figure"><a name="f01"></a><img alt="Figure
" src="qin00-0005-01.jpg"/></div><p>Ripretinib is a white to off-white crystalline solid. Ripretinib is a lipophilic, weak base, and practically insoluble in aqueous media.</p><p>QINLOCK is available as a white to off-white, oval tablets for oral use containing 50 mg of ripretinib. The tablet is debossed with “DC1” on one side. Each tablet contains the following inactive ingredients: crospovidone, hypromellose acetate succinate, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and silicon dioxide.</p></section>

QINLOCK

ripretinib

ripretinib 50 MG Oral Tablet

Qinlock

ripretinib 50 MG Oral Tablet [Qinlock]

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