Leukocyte Growth Factor

<section class="Section" data-sectioncode="34089-3"><a name="ID_a17342ba-742f-4dd8-98eb-49e58fcc50ff"></a><a name="section-9"></a><p></p><h1>11 DESCRIPTION </h1><p class="First">Eflapegrastim-xnst is a granulocyte colony-stimulating factor (G‑CSF) produced by covalent coupling of a human G-CSF analog (18.6 kDa) and an Fc fragment of human immunoglobulin G4 (IgG4) (49.8 kDa), both derived from recombinant <span class="Italics">E. coli</span>, via a single 3.4 kDa polyethylene glycol linker. The recombinant G-CSF domain in eflapegrastim-xnst is a variant of human G-CSF with two serine substitutions at positions 17 and 65, and no additional N-terminal methionine. Eflapegrastim-xnst has a molecular weight of approximately 72 kDa.  </p><p>Rolvedon (eflapegrastim-xnst) injection is a sterile, preservative-free, clear, colorless solution supplied in a single-dose prefilled syringe for subcutaneous use. Each 0.6 mL single-dose prefilled syringe contains 13.2 mg  of eflapegrastim-xnst, citric acid monohydrate (2.52 mg), mannitol (30 mg), polysorbate 80 (0.72 mg) and sodium chloride (5.26 mg) in Water for Injection. Sodium hydroxide may be used to adjust pH to 5.5 during manufacturing.</p></section>

Rolvedon

eflapegrastim

eflapegrastim-xnst

0.6 ML eflapegrastim-xnst 22 MG/ML Prefilled Syringe

0.6 ML eflapegrastim-xnst 22 MG/ML Prefilled Syringe [Rolvedon]

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Instructions For Use: Febrile Neutropenia 