Synthroid Drug Interactions: 67 Major, 884 Moderate
Synthroid (Levothyroxine Sodium) Drug Interactions
Check all documented drug-to-drug interactions. Major, moderate, and minor interactions with descriptions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Synthroid. Always confirm against the full prescribing information.
100 interactions
Abacavir
The risk or severity of liver damage can be increased when Levothyroxine is combined with Abacavir.
Level 2 evidence
Abatacept
The risk or severity of liver damage can be increased when Levothyroxine is combined with Abatacept.
Level 2 evidence
Abiraterone
The risk or severity of liver damage can be increased when Levothyroxine is combined with Abiraterone.
Level 2 evidence
Acalabrutinib
The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Acalabrutinib.
Level 1 evidence
Acamprosate
The risk or severity of liver damage can be increased when Levothyroxine is combined with Acamprosate.
Level 2 evidence
Acebutolol
The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Acebutolol.
Level 2 evidence
Aceclofenac
The risk or severity of liver damage can be increased when Levothyroxine is combined with Aceclofenac.
Level 2 evidence
Acetaminophen
The risk or severity of liver damage can be increased when Acetaminophen is combined with Levothyroxine.
Level 2 evidence
Acetazolamide
The risk or severity of liver damage can be increased when Levothyroxine is combined with Acetazolamide.
Level 2 evidence
Acetohydroxamic acid
The risk or severity of liver damage can be increased when Levothyroxine is combined with Acetohydroxamic acid.
Level 2 evidence
Acetylsalicylic acid
The therapeutic efficacy of Levothyroxine can be increased when used in combination with Acetylsalicylic acid.
Level 2 evidence
Acitretin
The risk or severity of liver damage can be increased when Levothyroxine is combined with Acitretin.
Level 2 evidence
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Synthroid (Levothyroxine Sodium) has 1021 documented drug interactions. Always review the full list with a pharmacist before co-prescribing.
Synthroid (Levothyroxine Sodium) has 67 major, 884 moderate, and 70 minor documented interactions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Synthroid. Always confirm against the full prescribing information.