Cytochrome P450 2C19 Inhibitors

Cytochrome P450 3A4 Inducers

Bipolar Disorder

Epilepsies, Partial

Epilepsy, Tonic-Clonic

Pain

Spasms, Infantile

Lennox Gastaut Syndrome

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-10"></a><h1>11 DESCRIPTION</h1>Topiramate, USP, is a sulfamate-substituted monosaccharide. TROKENDI XR ® (topiramate) extended-release capsules are available as 25 mg, 50 mg, 100 mg, and 200 mg capsules for oral administration. Topiramate is a white to off-white powder. Topiramate is freely soluble in polar organic solvents such as acetonitrile and acetone; and very slightly soluble to practically insoluble in non-polar organic solvents such as hexanes. Topiramate has the molecular formula C 12H 21NO 8S and a molecular weight of 339.4. Topiramate is designated chemically as 2,3:4,5-Di- O-isopropylidene-β-D-fructopyranose sulfamate and has the following structural formula: <img alt="Chemical Structure" src="trokendi-01.jpg"/>TROKENDI XR ® (topiramate) is an extended-release capsule. TROKENDI XR ® capsules contain the following inactive ingredients: Sugar Spheres, NF Hypromellose (Type 2910), USP Mannitol, USP Docusate Sodium, USP Sodium Benzoate, NF Ethylcellulose, NF Oleic Acid, NF Medium Chain Triglycerides, NF Polyethylene Glycol, NF Polyvinyl Alcohol, USP Titanium Dioxide, USP Talc, USP Lecithin, NF Xanthan Gum, NF Glycerin, USP-NF The capsule shells contain gelatin, USP; Titanium Dioxide, USP; and Colorants.The colorants are:FD&amp;C Blue #1 (all strength capsules) Yellow Iron Oxide, USP (25 mg and 50 mg capsules) FD&amp;C Red #3 (50 mg, 100 mg and 200 mg capsules) FD&amp;C Yellow #6 (50 mg, 100 mg and 200 mg capsules) Riboflavin, USP (25 mg capsules) All capsule shells are imprinted with black print that contains shellac, NF, and black iron oxide, NF.</section>

Trokendi XR

24 HR topiramate 50 MG Extended Release Oral Capsule

Trokendi

24 HR topiramate 50 MG Extended Release Oral Capsule [Trokendi]

24 HR topiramate 25 MG Extended Release Oral Capsule

24 HR topiramate 25 MG Extended Release Oral Capsule [Trokendi]

24 HR topiramate 100 MG Extended Release Oral Capsule

24 HR topiramate 100 MG Extended Release Oral Capsule [Trokendi]

24 HR topiramate 200 MG Extended Release Oral Capsule

24 HR topiramate 200 MG Extended Release Oral Capsule [Trokendi]

topiramate

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Report Adverse Event 

Submit MSL Request 

Prescribing Information 

Medication Guide 

Pharmacy List 

Online Sample Form 

Reimbursement Information

Coverage Authorization Request 

Coverage Authorization Appeals 

Enroll in Patient Savings Program 

Activate Co-pay Card (If already have one) 

Trokendi XR Patient Assistance Program Application 

Other HCP Resources: Migraine Prevention

About Trokendi XR: Seizures 

About Trokendi XR: Migraine Prevention 

FAQs: Migraine Prevention & Seizures 

Patient Stories: Migraine Prevention

Patient Resources: Migraine Prevention

Doctor Discussion Guide: Migraine Prevention

Instructions For Use: Migraine Prevention 

Instructions For Use: Seizures 