Integrin Receptor Antagonists

Integrin Receptor Antagonist

Crohn Disease

Multiple Sclerosis

<section class="Section" data-sectioncode="34089-3"><a name="s36"></a><a name="section-10"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">Natalizumab is a recombinant humanized IgG4κ monoclonal antibody produced in murine myeloma cells. Natalizumab contains human framework regions and the complementarity-determining regions of a murine antibody that binds to α4-integrin. The molecular weight of natalizumab is 149 kilodaltons.</p><p>TYSABRI (natalizumab) injection is supplied as a sterile, colorless, and clear to slightly opalescent solution for intravenous infusion. Each 15 mL of solution contains 300 mg natalizumab; sodium chloride, USP (123 mg); sodium phosphate, monobasic, monohydrate, USP (17 mg); sodium phosphate, dibasic, heptahydrate, USP (7.24 mg); polysorbate 80, USP/NF (3 mg), in Water for Injection, USP at pH 6.1.</p></section>

TYSABRI

natalizumab

15 ML natalizumab 20 MG/ML Injection

Tysabri

15 ML natalizumab 20 MG/ML Injection [Tysabri]

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Report Adverse Event 

Prescribing Information

Medication Guide 

Submit MSL Request 

Pharmacy List 

Reimbursement Information 

Reimbursement & Access Guide 

Coverage Authorization Request 

Coverage Authorization Appeals 

Letter of Medical Necessity - Treatment Naive 

Letter of Medical Necessity - Currently On Treatment 

Letter of Medical Necessity - Change of Treatment 

Letter of Medical Necessity - Site of Care Exceptions 

Enroll in Patient Savings Program 

Enroll in a Bridge Program 

TOUCH Prescribing Program 

Infusion Center Locator 

Peer Perspectives: Videos

Other HCP Resources

About Tysabri 

Tysabri Start Guide 

Side Effects

Receiving Tysabri 

Patient Stories 

Care Partner Resources 

Biogen Support Program 

Instructions for Use: Multiple Sclerosis 

Doctor Discussion Guide 