Opioid Antagonists

Opioid Antagonist

Alcoholism

Opioid-Related Disorders

Drug Overdose

<section class="Section" data-sectioncode="34089-3"><a name="s63"></a><a name="section-10"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">VIVITROL<span class="Sup">®</span> (naltrexone for extended-release injectable suspension) is supplied as a microsphere formulation of naltrexone for suspension, to be administered by deep intramuscular injection by a healthcare practitioner. VIVITROL contains naltrexone base anhydrous as the active pharmaceutical ingredient.  Naltrexone is an opioid antagonist with little, if any, opioid agonist activity.</p><p>Naltrexone is morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-(5α) (CAS Registry # 16590-41-3). The molecular formula is C<span class="Sub">20</span>H<span class="Sub">23</span>NO<span class="Sub">4</span> and its molecular weight is 341.41 in the anhydrous form (ie, &lt; 1% maximum water content). The structural formula is:</p><div class="Figure"><a name="f11"></a><img alt="Naltrexone Structural Formula
" src="viv03-0042-11.jpg"/></div><p>Naltrexone base anhydrous is an off-white to a light tan powder with a melting point of 168 °C to 170 °C (334 °F to 338 °F). It is insoluble in water and is soluble in ethanol.</p><p>VIVITROL is provided in a carton containing one vial of VIVITROL microspheres, one vial of diluent, one 5-mL syringe, one 1-inch 20-gauge preparation needle, two 1 1/2-inch 20-gauge, and two 2-inch 20-gauge administration needles with needle protection device.</p><p>VIVITROL microspheres consist of a sterile, off-white to light tan powder that is available in a dosage strength of 380 mg of naltrexone per vial. Naltrexone base anhydrous is incorporated in a biodegradable matrix of 75:25 polylactide-co-glycolide (PLG) at a concentration of 337 mg of naltrexone per gram of microspheres.</p><p>The diluent is a clear, colorless solution. Each mL of diluent contains 30.0 mg of carboxymethylcellulose sodium, 1.0 mg of polysorbate 20, 9.0 mg of sodium chloride, and  sodium hydroxide and hydrochloric acid as pH adjusters, in water for injection. The pH of the diluent is in the range of 5.8 to 7.2.</p></section>

VIVITROL

Vivitrol

naltrexone 380 MG Injection

naltrexone 380 MG Injection [Vivitrol]

naltrexone

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Report Adverse Event 

Prescribing Information 

Medication Guide 

Submit MSL Request 

Pharmacy List 

Online Sample Form 

Formulary Information 

Billing & Coding  Guide 

Buy & Bill Portal: HCP Office 

Coverage Authorization Request 

Coverage Authorization Appeals 

Vivitrol2gether Patient Enrollment Form 

Enroll in Patient Savings Program 

Prescribing Vivitrol

Other HCP Resources 

About Vivitrol: Alcohol Dependence 

FAQs: Alcohol Dependence 

Patient Stories: Alcohol Dependence 

Vivitrol2gether Support Program: Alcohol Dependence 

Instructions For Use: Alcohol Dependence 

Doctor Discussion Guide: Alcohol Dependence

About Vivitrol: Opioid Dependence 

FAQs: Opioid Dependence

Patient Stories: Opioid Dependence 

Vivitrol2gether Support Program: Opioid Dependence 

Instructions For Use: Opioid Dependence 

Doctor Discussion Guide: Opioid Dependence 

Emergency Pain Management Card 

Treatment Goals Worksheet