Check all documented drug-to-drug interactions. Major, moderate, and minor interactions with descriptions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Xyrem. Always confirm against the full prescribing information.
100 interactions
Alfentanil
The risk or severity of CNS depression can be increased when Alfentanil is combined with Sodium oxybate.
Level 2 evidence
Apomorphine
The risk or severity of CNS depression can be increased when Apomorphine is combined with Sodium oxybate.
Level 2 evidence
Aripiprazole lauroxil
The risk or severity of CNS depression can be increased when Sodium oxybate is combined with Aripiprazole lauroxil.
Level 2 evidence
Articaine
The risk or severity of CNS depression can be increased when Articaine is combined with Sodium oxybate.
Level 2 evidence
Botulinum toxin type A
The risk or severity of CNS depression can be increased when Botulinum toxin type A is combined with Sodium oxybate.
Level 2 evidence
Botulinum toxin type B
The risk or severity of CNS depression can be increased when Botulinum toxin type B is combined with Sodium oxybate.
Level 2 evidence
Brexanolone
The risk or severity of CNS depression can be increased when Sodium oxybate is combined with Brexanolone.
Level 2 evidence
Brimonidine
Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Level 2 evidence
Bupivacaine
The risk or severity of CNS depression can be increased when Bupivacaine is combined with Sodium oxybate.
Level 2 evidence
Butorphanol
The risk or severity of CNS depression can be increased when Butorphanol is combined with Sodium oxybate.
Level 2 evidence
Chloroprocaine
The risk or severity of CNS depression can be increased when Chloroprocaine is combined with Sodium oxybate.
Level 2 evidence
Cisatracurium
The risk or severity of CNS depression can be increased when Cisatracurium is combined with Sodium oxybate.
Level 2 evidence
Enter your NPI to unlock 86 major interactions for Xyrem
Xyrem (Sodium Oxybate) has 269 documented drug interactions. Always review the full list with a pharmacist before co-prescribing.
Xyrem (Sodium Oxybate) has 231 major, 37 moderate, and 1 minor documented interactions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Xyrem. Always confirm against the full prescribing information.