Zoloft (Sertraline Hydrochloride) Drug Interactions
Check all documented drug-to-drug interactions. Major, moderate, and minor interactions with descriptions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Zoloft. Always confirm against the full prescribing information.
100 interactions
Abacavir
The risk or severity of liver damage can be increased when Abacavir is combined with Sertraline.
Level 2 evidence
Abatacept
The metabolism of Sertraline can be increased when combined with Abatacept.
Level 1 evidence
Abemaciclib
The risk or severity of liver damage can be increased when Sertraline is combined with Abemaciclib.
Level 2 evidence
Abiraterone
The metabolism of Sertraline can be decreased when combined with Abiraterone.
Level 1 evidence
Abrocitinib
The metabolism of Abrocitinib can be decreased when combined with Sertraline.
Level 2 evidence
Acalabrutinib
The risk or severity of liver damage can be increased when Sertraline is combined with Acalabrutinib.
Level 2 evidence
Acamprosate
The risk or severity of liver damage can be increased when Acamprosate is combined with Sertraline.
Level 2 evidence
Acarbose
The risk or severity of hypoglycemia can be increased when Sertraline is combined with Acarbose.
Level 2 evidence
Acebutolol
The serum concentration of Acebutolol can be increased when it is combined with Sertraline.
Level 2 evidence
Aceclofenac
The risk or severity of bleeding can be increased when Aceclofenac is combined with Sertraline.
Level 1 evidence
Acenocoumarol
The risk or severity of bleeding can be increased when Sertraline is combined with Acenocoumarol.
Level 1 evidence
Acetaminophen
The risk or severity of liver damage can be increased when Acetaminophen is combined with Sertraline.
Level 2 evidence
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Zoloft (Sertraline Hydrochloride) has 1193 documented drug interactions. Always review the full list with a pharmacist before co-prescribing.
Zoloft (Sertraline Hydrochloride) has 99 major, 1011 moderate, and 83 minor documented interactions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Zoloft. Always confirm against the full prescribing information.