| Acne Vulgaris
Clindagel vs Onexton
Side-by-side clinical, coverage, and cost comparison for acne vulgaris.Deep comparison between: Clindagel vs Onexton with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsOnexton has a higher rate of injection site reactions vs Clindagel based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Onexton but not Clindagel, including UnitedHealthcare
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Category
Clindagel
Onexton
At A Glance
Topical
Once daily
Topical antibiotic (lincosamide)
Topical
Once daily
Antibiotic/keratolytic combination
Indications
- Acne Vulgaris
- Acne Vulgaris
Dosing
Acne Vulgaris Apply a thin film once daily to the skin where acne lesions appear, covering the entire affected area lightly.
Acne Vulgaris Apply a pea-sized amount to the face once daily; wash face gently with mild soap, rinse with warm water, and pat dry before applying. Avoid eyes, mouth, mucous membranes, and areas of broken skin.
Contraindications
- History of hypersensitivity to preparations containing clindamycin or lincomycin
- History of regional enteritis or ulcerative colitis
- History of antibiotic-associated colitis
- Hypersensitivity (e.g., anaphylaxis) to clindamycin, benzoyl peroxide, any components of the formulation, or lincomycin
- History of regional enteritis, ulcerative colitis, or antibiotic-associated colitis
Adverse Reactions
Most common (>=1%) Pruritus, peeling
Serious Severe colitis, pseudomembranous colitis, diarrhea, bloody diarrhea, abdominal pain, gram-negative folliculitis
Most common (<0.5%) Burning sensation, contact dermatitis, pruritus, rash
Postmarketing Anaphylaxis, allergic reactions leading to hospitalization
Pharmacology
Clindamycin phosphate is a semi-synthetic lincosamide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, suppressing Propionibacterium acnes growth.
Clindamycin is a lincosamide antibacterial that binds to the 50S ribosomal subunit of susceptible bacteria and suppresses protein synthesis by interfering with peptidyl transfer; benzoyl peroxide is an oxidizing agent with bactericidal and keratolytic effects, though its precise mechanism is unknown.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Clindagel
- Covered on 5 commercial plans
- PA (1/12) · Step Therapy (0/12) · Qty limit (9/12)
Onexton
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
UnitedHealthcare
Clindagel
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (7/8)
Onexton
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (1/8) · Qty limit (0/8)
Humana
Clindagel
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (0/3) · Qty limit (2/3)
Onexton
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Clindagel.
No savings programs available for Onexton.
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ClindagelView full Clindagel profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.