| Acne Vulgaris
Clindagel vs Seysara
Side-by-side clinical, coverage, and cost comparison for acne vulgaris.Deep comparison between: Clindagel vs Seysara with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsSeysara has a higher rate of injection site reactions vs Clindagel based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Seysara but not Clindagel, including UnitedHealthcare
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Category
Clindagel
Seysara
At A Glance
Topical
Once daily
Topical antibiotic (lincosamide)
Oral
Daily
Tetracycline-class antibiotic
Indications
- Acne Vulgaris
- Acne Vulgaris
Dosing
Acne Vulgaris Apply a thin film once daily to the skin where acne lesions appear, covering the entire affected area lightly.
Acne Vulgaris Weight-based once-daily oral dosing: 60 mg (33-54 kg), 100 mg (55-84 kg), or 150 mg (85-136 kg); take with or without food and adequate fluid; reassess if no improvement after 12 weeks.
Contraindications
- History of hypersensitivity to preparations containing clindamycin or lincomycin
- History of regional enteritis or ulcerative colitis
- History of antibiotic-associated colitis
- Hypersensitivity to any tetracycline
Adverse Reactions
Most common (>=1%) Pruritus, peeling
Serious Severe colitis, pseudomembranous colitis, diarrhea, bloody diarrhea, abdominal pain, gram-negative folliculitis
Most common (>=1%) Nausea
Less common (<1%, female subjects) Vulvovaginal mycotic infection, vulvovaginal candidiasis
Pharmacology
Clindamycin phosphate is a semi-synthetic lincosamide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, suppressing Propionibacterium acnes growth.
Sarecycline is an aminomethylcycline within the tetracycline class that binds to the 30S ribosomal subunit and blocks protein synthesis in Propionibacterium acnes; its precise mechanism for treating the inflammatory lesions of non-nodular acne vulgaris is not known.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Clindagel
- Covered on 5 commercial plans
- PA (1/12) · Step Therapy (0/12) · Qty limit (9/12)
Seysara
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (9/12) · Qty limit (9/12)
UnitedHealthcare
Clindagel
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (7/8)
Seysara
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Clindagel
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (0/3) · Qty limit (2/3)
Seysara
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (2/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Clindagel.
No savings programs available for Seysara.
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ClindagelView full Clindagel profile
SeysaraView full Seysara profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.