| Actinic keratosis
Ameluz vs Klisyri
Side-by-side clinical, coverage, and cost comparison for actinic keratosis.Deep comparison between: Ameluz vs Klisyri with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsKlisyri has a higher rate of injection site reactions vs Ameluz based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Klisyri but not Ameluz, including UnitedHealthcare
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Category
Ameluz
Klisyri
At A Glance
Topical
Single treatment session; retreat at 3 months if needed
Porphyrin precursor (photosensitizer)
Topical
Daily for 5 days
Microtubule inhibitor
Indications
- Actinic keratosis
- Actinic keratosis
Dosing
Actinic keratosis Apply approximately 1 mm thick layer of AMELUZ to lesion(s) and approximately 5 mm of surrounding skin (max area 60 cm2, max 6 g/3 tubes at one time); allow to dry ~10 minutes, occlude for 3 hours, then illuminate immediately with BF-RhodoLED or RhodoLED XL red light; retreat lesions not completely resolved after 3 months.
Actinic keratosis Apply evenly to cover up to 100 cm2 treatment field on the face or balding scalp once daily for 5 consecutive days using 1 unit-dose packet per application; topical.
Contraindications
- Known hypersensitivity to porphyrins
- Known hypersensitivity to any component of AMELUZ, including soybean phosphatidylcholine
- Porphyria (uncontrolled phototoxic effects may occur)
- Photodermatoses (PDT may worsen phototoxic or photoallergic reactions)
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Adverse Reactions
Most common (>=1%) Application site erythema, pain/burning, irritation, edema, pruritus, exfoliation, scab, induration, vesicles, paresthesia, hyperalgesia, discomfort, erosion, discharge, bleeding, pustules
Serious Severe pain/burning (up to 30-41% of subjects), allergic contact dermatitis, hypersensitivity reactions
Postmarketing Allergic dermatitis, application site inflammation, application site discoloration, eye irritation, diplopia, ocular hyperemia, photophobia, blurred vision, fatigue, hypersensitivity, dysaesthesia, transient amnestic episodes
Most common (>=2%) Local skin reactions (erythema, flaking/scaling, crusting, swelling, vesiculation/pustulation, erosion/ulceration), application site pruritus, application site pain
Pharmacology
Porphyrin precursor prodrug; aminolevulinic acid is metabolized in the skin to protoporphyrin IX (PpIX), which upon activation by red light (~635 nm) generates reactive oxygen species in the presence of oxygen, causing cellular damage and destruction of actinic keratosis lesions.
Tirbanibulin is a microtubule inhibitor; the mechanism of action for the topical treatment of actinic keratosis is unknown.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Ameluz
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (0/12) · Qty limit (0/12)
Klisyri
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (9/12) · Qty limit (0/12)
UnitedHealthcare
Ameluz
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Klisyri
- Covered on 4 commercial plans
- PA (3/8) · Step Therapy (7/8) · Qty limit (4/8)
Humana
Ameluz
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Klisyri
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Ameluz.
No savings programs available for Klisyri.
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AmeluzView full Ameluz profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.