| Actinic keratosis
Klisyri vs Ameluz
Side-by-side clinical, coverage, and cost comparison for actinic keratosis.Deep comparison between: Klisyri vs Ameluz with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsAmeluz has a higher rate of injection site reactions vs Klisyri based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Ameluz but not Klisyri, including UnitedHealthcare
Sign up to reveal the full AI analysis
Category
Klisyri
Ameluz
At A Glance
Topical
Daily for 5 days
Microtubule inhibitor
Topical
Single treatment session; retreat at 3 months if needed
Porphyrin precursor (photosensitizer)
Indications
- Actinic keratosis
- Actinic keratosis
Dosing
Actinic keratosis Apply evenly to cover up to 100 cm2 treatment field on the face or balding scalp once daily for 5 consecutive days using 1 unit-dose packet per application; topical.
Actinic keratosis Apply approximately 1 mm thick layer of AMELUZ to lesion(s) and approximately 5 mm of surrounding skin (max area 60 cm2, max 6 g/3 tubes at one time); allow to dry ~10 minutes, occlude for 3 hours, then illuminate immediately with BF-RhodoLED or RhodoLED XL red light; retreat lesions not completely resolved after 3 months.
Contraindications
—
- Known hypersensitivity to porphyrins
- Known hypersensitivity to any component of AMELUZ, including soybean phosphatidylcholine
- Porphyria (uncontrolled phototoxic effects may occur)
- Photodermatoses (PDT may worsen phototoxic or photoallergic reactions)
Adverse Reactions
Most common (>=2%) Local skin reactions (erythema, flaking/scaling, crusting, swelling, vesiculation/pustulation, erosion/ulceration), application site pruritus, application site pain
Most common (>=1%) Application site erythema, pain/burning, irritation, edema, pruritus, exfoliation, scab, induration, vesicles, paresthesia, hyperalgesia, discomfort, erosion, discharge, bleeding, pustules
Serious Severe pain/burning (up to 30-41% of subjects), allergic contact dermatitis, hypersensitivity reactions
Postmarketing Allergic dermatitis, application site inflammation, application site discoloration, eye irritation, diplopia, ocular hyperemia, photophobia, blurred vision, fatigue, hypersensitivity, dysaesthesia, transient amnestic episodes
Pharmacology
Tirbanibulin is a microtubule inhibitor; the mechanism of action for the topical treatment of actinic keratosis is unknown.
Porphyrin precursor prodrug; aminolevulinic acid is metabolized in the skin to protoporphyrin IX (PpIX), which upon activation by red light (~635 nm) generates reactive oxygen species in the presence of oxygen, causing cellular damage and destruction of actinic keratosis lesions.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Klisyri
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (9/12) · Qty limit (0/12)
Ameluz
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Klisyri
- Covered on 4 commercial plans
- PA (3/8) · Step Therapy (7/8) · Qty limit (4/8)
Ameluz
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Klisyri
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (2/3)
Ameluz
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Klisyri.
No savings programs available for Ameluz.
Compare Other Drugs
Let us handle your prior authsJust enter your patient's info and we'll:
- Verify eligibility with the payer.
- Pull the right PA forms directly from the payer.
- Submit, track & send live updates to your dashboard.
Free to start · HIPAA compliant
Next Steps for Your Patient
KlisyriView full Klisyri profile
AmeluzView full Ameluz profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.